Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate

Base Information

Chemical Name:Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate
CAS No.:104537-94-2
Molecular Formula:C₁₈H₁₄N₂O₄
Molecular Weight:322.32
Hs Code.:2934999090
DSSTox Substance ID:DTXSID50418833
Wikidata:Q82229532
Mol file:104537-94-2.mol

Synonyms:Flazin, methyl ester;104537-94-2;Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate;methyl 1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylate;DTXSID50418833;BQMIHWBNJGZYRR-UHFFFAOYSA-N;methyl 1-[5-(hydroxymethyl)-2-furyl]-9h-b-carboline-3-carboxylate;Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate #

Suppliers and Price of Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate

Chemical Property:

PSA：88.35000
LogP:3.25500
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:322.09535693
Heavy Atom Count:24
Complexity:474

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=NC(=C2C(=C1)C3=CC=CC=C3N2)C4=CC=C(O4)CO

Technology Process of Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate

There total 5 articles about Methyl 1-[5-(hydroxymethyl)-2-furyl]-9H-beta-carboline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 100041-05-2
1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid

: 104537-94-2
1-(5-Hydroxymethyl-2-furyl)-3-carbomethoxy-9H-pyrido<3,4-b>indole

Guidance literature:: In methanol;
DOI:10.1016/S0040-4039(00)84806-6

Reference yield: 85.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1108154-96-6
methyl 1-(furan-2-yl)-9H-pyrido[3,4-b]indole-3-carboxylate

: 104537-94-2
1-(5-Hydroxymethyl-2-furyl)-3-carbomethoxy-9H-pyrido<3,4-b>indole

Guidance literature:: With acetic acid; In water; for 3h; Reflux;
DOI:10.1039/c7ra13434g

Reference yield:

: 1-(5-Acetoxymethyl-2-furyl)-3-carbomethoxy-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole

: 104537-94-2
1-(5-Hydroxymethyl-2-furyl)-3-carbomethoxy-9H-pyrido<3,4-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / oxygen / 5percent Pt/C / toluene / 12 h / Heating

2: conc. aq. NH₄OH / methanol / 2 h / Ambient temperature

With ammonium hydroxide; oxygen; platinum on activated charcoal; In methanol; toluene;
DOI:10.1002/ardp.19883210212