(2s)-2-(Methoxymethyl)-1-pyrrolidinecarbonyl chloride

Base Information

• Chemical Name: (2s)-2-(Methoxymethyl)-1-pyrrolidinecarbonyl chloride
• CAS No.: 204580-51-8
• Molecular Formula: C7H12ClNO2
• Molecular Weight: 177.631
• DSSTox Substance ID: DTXSID801216365
• Mol file: 204580-51-8.mol

Synonyms:204580-51-8;(2s)-2-(methoxymethyl)-1-pyrrolidinecarbonyl chloride;SCHEMBL3055321;DTXSID801216365

Chemical Property of (2s)-2-(Methoxymethyl)-1-pyrrolidinecarbonyl chloride

Chemical Property:

• PSA: 29.54000
• LogP: 1.39390
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 177.0556563
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1CCCN1C(=O)Cl
• Isomeric SMILES: COC[C@@H]1CCCN1C(=O)Cl

Technology Process of (2s)-2-(Methoxymethyl)-1-pyrrolidinecarbonyl chloride

There total 1 articles about (2s)-2-(Methoxymethyl)-1-pyrrolidinecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

phosgene (75-44-5) + (2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) → (S)-2-Methoxymethyl-pyrrolidine-1-carbonyl chloride (204580-51-8)

Guidance literature:

In toluene; at -10 ℃; for 5h;

DOI:10.1016/S0040-4020(98)00504-3

Reference yield: 83.0%

2-[(4-hydroxyphenyl)thio]-7-isopropoxy-5,6-dimethoxy-4H-chromen-4-one (144553-76-4) + (S)-2-Methoxymethyl-pyrrolidine-1-carbonyl chloride (204580-51-8) → 7-isopropoxy-5,6-dimethoxy-2-{{4-{{[(S)-2-(methoxymethyl)-1-pyrrolidinyl]carbonyl}oxy}phenyl}thio}-4H-chromen-4-one

Guidance literature:

With pyridine; at 50 ℃; for 7h;

DOI:10.1248/cpb.55.328

upstream raw materials:

phosgene

(2S)-2-(methoxymethyl)-1-pyrrolidine