Technology Process of 3-BroMo-5-fluoro-2-Methyl-pyridine
There total 1 articles about 3-BroMo-5-fluoro-2-Methyl-pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 110 ℃;
for 16h;
Inert atmosphere;
sealed tube;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: selenium(IV) oxide / 1,4-dioxane / 16 h / 80 °C
2: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 20 °C
3: acetic anhydride / 18 h / 100 - 140 °C
4: caesium carbonate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione / 1,4-dioxane / 18 h / 120 °C / Sealed tube; Inert atmosphere
With
1,4-diaza-bicyclo[2.2.2]octane; selenium(IV) oxide; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; acetic anhydride; caesium carbonate;
In
1,4-dioxane;
DOI:10.1021/ja408917n
- Guidance literature:
-
Multi-step reaction with 5 steps
1: selenium(IV) oxide / 1,4-dioxane / 16 h / 80 °C
2: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 20 °C
3: acetic anhydride / 18 h / 100 - 140 °C
4: caesium carbonate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione / 1,4-dioxane / 18 h / 120 °C / Sealed tube; Inert atmosphere
5: boron tribromide / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere
With
1,4-diaza-bicyclo[2.2.2]octane; selenium(IV) oxide; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; acetic anhydride; boron tribromide; caesium carbonate;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/ja408917n
