8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

Base Information

• Chemical Name: 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine
• CAS No.: 1314874-80-0
• Molecular Formula: C5H4ClN5
• Molecular Weight: 169.573
• Mol file: 1314874-80-0.mol

Synonyms:8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine;8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine

Chemical Property of 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

Chemical Property:

• PKA: 1.40±0.30(Predicted)
• PSA: 69.10000
• Density: 1.95±0.1 g/cm3(Predicted)
• LogP: 0.94110

Purity/Quality:

NLT 98% ^*data from raw suppliers

8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-amine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

There total 1 articles about 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl N-[(3-chloropyrazin-2-yl)carbamothioyl]carbamate (1314874-79-7) → 8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine (1314874-80-0)

Guidance literature:

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; at 20 ℃; for 1h;

ethyl N-[(3-chloropyrazin-2-yl)carbamothioyl]carbamate; for 2h; Reflux;

Reference yield:

8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine (1314874-80-0) + (meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → C12H8F3N5 (1314874-81-1)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 95 ℃; for 18h; Inert atmosphere;

Reference yield:

8-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine (1314874-80-0) + 2-hydroxyphenyl boronic acid (89466-08-0) → C11H9N5O (1360612-71-0)

Guidance literature:

With potassium phosphate; potassium hydroxide; trans-bis(tricyclohexylphosphine)palladium(II) dichloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 150 ℃; for 2h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

ethyl N-[(3-chloropyrazin-2-yl)carbamothioyl]carbamate

Downstream raw materials:

C₁₂H₈F₃N₅

N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazin-2-amine

3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

C₂₅H₂₆F₃N₇O₂