3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

Base Information

Chemical Name:3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine
CAS No.:1314873-89-6
Molecular Formula:C₂₃H₂₄F₃N₇O
Molecular Weight:471.485
Hs Code.:

Synonyms:3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

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Chemical Property of 3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

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Technology Process of 3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

There total 8 articles about 3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1314786-27-0
N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-8-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazin-2-amine

: 1314873-89-6
3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

Guidance literature:: With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; isopropyl alcohol; at 25 ℃; Inert atmosphere;

Reference yield:

: 454-16-0
1-fluoro-2-methoxy-4-nitrobenzene

: 1314873-89-6
3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 125 °C / Inert atmosphere

2.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C / Inert atmosphere

3.1: sodium nitrite; sulfuric acid / acetic acid / 0.5 h / 10 - 20 °C

3.2: 1 h / 20 °C

4.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 20 h / 100 °C / Inert atmosphere

5.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / isopropyl alcohol; methanol / 25 °C / Inert atmosphere

With thiophene; hydrogenchloride; sulfuric acid; hydrogen; potassium carbonate; caesium carbonate; sodium nitrite; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; acetic acid; dimethyl sulfoxide; isopropyl alcohol; tert-butyl alcohol;

Reference yield:

: 870838-56-5
1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

: 1314873-89-6
3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]amino]-5-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,4-triazole-1-ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-butyl alcohol / 20 h / 100 °C / Inert atmosphere

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / isopropyl alcohol; methanol / 25 °C / Inert atmosphere

With hydrogenchloride; hydrogen; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; isopropyl alcohol; tert-butyl alcohol;