2-fluoro-6-(1-trityl-1H-imidazol-4-yl)benz aldehyde

Base Information

Chemical Name:2-fluoro-6-(1-trityl-1H-imidazol-4-yl)benz aldehyde
CAS No.:1402838-09-8
Molecular Formula:C29H21FN2O
Molecular Weight:432.497
Hs Code.:
Mol file:1402838-09-8.mol

Synonyms:2-fluoro-6-(1-trityl-1H-imidazol-4-yl)benz aldehyde;2-fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde

Suppliers and Price of 2-fluoro-6-(1-trityl-1H-imidazol-4-yl)benz aldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde
50mg
$ 130.00

Crysdot
2-Fluoro-6-(1-trityl-1H-imidazol-4-yl)benzaldehyde 97%
5g
$ 1646.00

Crysdot
2-Fluoro-6-(1-trityl-1H-imidazol-4-yl)benzaldehyde 97%
1g
$ 548.00

Chemenu
2-Fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde 95%+
250mg
$ 402.00

Chemenu
2-Fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde 95%+
1g
$ 1078.00

AK Scientific
2-Fluoro-6-(1-trityl-1H-imidazol-4-yl)benzaldehyde
1g
$ 937.00

Total 12 raw suppliers

Chemical Property of 2-fluoro-6-(1-trityl-1H-imidazol-4-yl)benz aldehyde

Chemical Property:

Boiling Point:601.1±55.0 °C(Predicted)
PKA:4.65±0.12(Predicted)
PSA：34.89000
Density:1.14±0.1 g/cm3(Predicted)
LogP:6.34190

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-fluoro-6-(1-trityl-1H-imidazol-4-yl)benz aldehyde

There total 2 articles about 2-fluoro-6-(1-trityl-1H-imidazol-4-yl)benz aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 871126-15-7
(3-fluoro-2-formylphenyl)boronic acid

: 96797-15-8
N-trityl-4⁽⁵⁾-iodoimidazole

: 1402838-09-8
2-fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00662

Reference yield:

: 76-83-5
trityl chloride

: 1402838-09-8
2-fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.3390/molecules24112124

Reference yield: 95.0%

: dimethyl 2-(4-(tert-butyldimethylsilyloxy)cyclohexyl)-2-oxoethylphosphonate

: 1402838-09-8
2-fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde

: 2-(6-fluoro-5H-imidazo[5,1-α]isoindol-5-yl)-1-((trans)-4-hydroxycyclohexyl)ethanone

Guidance literature:: dimethyl 2-(4-(tert-butyldimethylsilyloxy)cyclohexyl)-2-oxoethylphosphonate; 2-fluoro-6-[1-(triphenylmethyl)-1H-imidazol-4-yl]benzaldehyde; With sodium hydride; In tetrahydrofuran; at -10 - 20 ℃; for 2h;

With acetic acid; In methanol; at 90 ℃; for 1.5h;

With hydrogenchloride; In methanol; water; at 50 ℃; for 0.5h;