871126-15-7

Basic information

• Product Name: 3-FLUORO-2-FORMYLPHENYLBORONIC ACID
• Synonyms: 3-Fluoro-2-forMylbenzeneboronic acid;3-Fluoro-2-formylphenylboronic acid >=95%;3-Fluoro-2-formylphenylboronic Acid (contains varying amounts of Anhydride);Boronic acid, (3-fluoro-2-formylphenyl)-;3-FLUORO-2-FORMYLPHENYLBORONIC ACID
• CAS NO: 871126-15-7
• Molecular Formula: C7H6BFO3
• Molecular Weight: 167.9301432
• Product Categories: Aldehydes;Aryl Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Building Blocks;C7;Carbonyl Compounds;Chemical Synthesis;Disubstituted Aryl Boronic Acids;Organic Building Blocks;Organometallic Reagents
• Mol File: 871126-15-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 123-127℃
• Boiling Point: 357.4±52.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.15±0.53(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-FLUORO-2-FORMYLPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-2-FORMYLPHENYLBORONIC ACID(871126-15-7)
• EPA Substance Registry System: 3-FLUORO-2-FORMYLPHENYLBORONIC ACID(871126-15-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 871126-15-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 871126-15-7 differently. You can refer to the following data:
1. ? ;Undergoes unprecedented tautomeric rearrangement in solution1
2. Undergoes unprecedented tautomeric rearrangement in solution.

Upstream product

• 1246633-35-1 2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 959687-72-0 1-bromo-2-(dimethoxymethyl)-3-fluorobenzene 
• 121-43-7 Trimethyl borate 
• 448-53-3 tris(3-fluoro phenyl)boroxine 
• 7732-18-5 water 
• 109-94-4 formic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 360575-28-6 2-bromo-6-fluorobenzaldehyde 
• 150-46-9 triethyl borate 

Relevant articles and documents

Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases

The production of β-lactamases represents the main cause of resistance to clinically important β-lactam antibiotics. Boron containing compounds have been demonstrated as promising broad-spectrum β-lactamase inhibitors to combat β-lactam resistance. Here we report a series of 3-aryl substituted benzoxaborole derivatives, which manifested broad-spectrum inhibition to representative serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs). The most potent inhibitor 9f displayed an IC50 value of 86 nM to KPC-2 SBL and micromolar inhibitory activity towards other tested enzymes. Cell-based assays further revealed that 9f was able to significantly reduce the MICs of meropenem in clinically isolated KPC-2-producing bacterial strains and it showed no apparent toxicity in HEK293T cells.

Method for preparing 3-fluorine-2-aldehyde phenylboronic acid

The invention discloses a method for preparing 3-fluorine-2-aldehyde phenylboronic acid. Starting from 3-fluorine phenylboronic acid, tripolymer is formed after heating reflux in methylbenzene or heptane and dehydration, then a lithium reagent is added to