Compound 7P

Base Information

• Chemical Name: Compound 7P
• CAS No.: 1890208-58-8
• Molecular Weight: 441.5
• Mol file: 1890208-58-8.mol

Synonyms:Compound 7P;High purity CAS 1890208-58-8 Compound 7P in stock;2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide;Acetamide, 2-[(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)-

Chemical Property of Compound 7P

Chemical Property:

• PKA: 11?+-.0.70(Predicted)
• Density: 1.329±0.06 g/cm3(Predicted)

Purity/Quality:

99.89% ^*data from raw suppliers

2-((N-(2-Methoxyphenyl)-4-methylphenyl)sulfonamido)-N-(4-methoxypyridin-3-yl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Compound 7P

There total 5 articles about Compound 7P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-methoxypyridin-3-amine (33631-09-3) + 2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)acetic acid → 2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide (1890208-58-8)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.6b00015

Reference yield:

2-methoxy-phenylamine (90-04-0) → 2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide (1890208-58-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3: sodium hydroxide / tetrahydrofuran / 6 h / Reflux

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.6b00015

Reference yield:

N-tosyl-2-anisidine (6295-94-9) → 2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide (1890208-58-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: sodium hydroxide / tetrahydrofuran / 6 h / Reflux

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With potassium carbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.6b00015

upstream raw materials:

2-methoxy-phenylamine

N-tosyl-2-anisidine

4-methoxypyridin-3-amine

p-toluenesulfonyl chloride

Refernces