3-Amino-4-methoxypyridine

Base Information

• Chemical Name: 3-Amino-4-methoxypyridine
• CAS No.: 33631-09-3
• Molecular Formula: C6H8 N2 O
• Molecular Weight: 124.142
• Hs Code.: 29339900
• European Community (EC) Number: 640-774-2
• DSSTox Substance ID: DTXSID30409446
• Wikidata: Q72438961
• Mol file: 33631-09-3.mol

Synonyms:3-AMINO-4-METHOXYPYRIDINE;33631-09-3;4-methoxypyridin-3-amine;MFCD07374959;3-PYRIDINAMINE, 4-METHOXY-;4-Methoxy-pyridin-3-ylamine;3-amino-4methoxypryidine;3-Amino4 methoxypyridine;3-Amino-4-methoxypyridin;3- Amino-4 methoxypyridine;SCHEMBL934648;(4-Methoxypyridin-3-yl)amine;4-METHOXY-3-PYRIDINAMINE;DTXSID30409446;STWMPIWLSQKHSJ-UHFFFAOYSA-N;AKOS005199473;3-amino-4-methoxypyridine, AldrichCPR;AB40817;CS-W000346;PS-5097;SY019773;FT-0649985;EN300-61074;A23234;3-Pyridinamine, 4-methoxy-, hydrochloride (1:2);J-019281;J-515674;Z359373528

Chemical Property of 3-Amino-4-methoxypyridine

Chemical Property:

• Vapor Pressure: 0.00684mmHg at 25°C
• Melting Point: 83 °C
• Refractive Index: 1.56
• Boiling Point: 270.4oC at 760 mmHg
• PKA: 7.48±0.18(Predicted)
• Flash Point: 117.4oC
• PSA: 48.14000
• Density: 1.139g/cm3
• LogP: 1.25360
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-4-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=NC=C1)N

Technology Process of 3-Amino-4-methoxypyridine

There total 2 articles about 3-Amino-4-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-3-nitro-pyridine (31872-62-5) → 4-methoxypyridin-3-amine (33631-09-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 6h; under 2585.81 Torr;

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → 4-methoxypyridin-3-amine (33631-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0 °C / Inert atmosphere

2: hydrogenchloride; iron / methanol; water / Inert atmosphere

With hydrogenchloride; iron; In methanol; water;

DOI:10.1039/c2ob25926e

Reference yield: 83.0%

4-methoxypyridin-3-amine (33631-09-3) + 2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)acetic acid → C21H21N3O5S

Guidance literature:

2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)acetic acid; With thionyl chloride; In dichloromethane; at 0 - 10 ℃; for 3h; Reflux; Industrial scale;

4-methoxypyridin-3-amine; In dichloromethane; at 0 - 10 ℃; for 1.5h; Industrial scale;

upstream raw materials:

4-methoxy-3-nitro-pyridine

4-hydroxy-3-nitropyridine

Downstream raw materials:

2-bromo-4-methoxy-pyridin-3-amine

4-methoxypyridine-3-carbonitrile

2-bromo-3-fluoro-4-methoxypyridine

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