(1R)-6-FLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE

Base Information

• Chemical Name: (1R)-6-FLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE
• CAS No.: 1057246-78-2
• Molecular Formula: C10H12FN
• Molecular Weight: 165.2073832
• Mol file: 1057246-78-2.mol

Synonyms:(1R)-6-FLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE;(R)-6-Fluoro-1,2,3,4-tetrahydro-naphthalen-1-ylamine;(R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

Chemical Property of (1R)-6-FLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE

Chemical Property:

• Boiling Point: 247.6±40.0 °C(Predicted)
• PKA: 9.33±0.20(Predicted)
• PSA: 26.02000
• Density: 1.115±0.06 g/cm3(Predicted)
• LogP: 2.86210

Purity/Quality:

98% ^*data from raw suppliers

(1R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-6-FLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE

There total 3 articles about (1R)-6-FLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 6-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (1057246-78-2,1213465-25-8,1220039-98-4)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In ethanol; at 130 ℃; Sealed tube; Microwave irradiation;

Reference yield: 65.0%

(Z)-6-fluoro-3,4-dihydronaphthalen-1(2H)-one oxime → 6-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (1057246-78-2,1213465-25-8,1220039-98-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; at 20 ℃; for 12h;

Reference yield:

6-fluoro-3,4-dihydronaphthalen-1(2H)-one (703-67-3) → 6-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (1057246-78-2,1213465-25-8,1220039-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 12 h / 90 °C

2: palladium on activated charcoal; hydrogen; acetic acid / methanol / 12 h / 20 °C

With palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic acid; In methanol; ethanol; water;

upstream raw materials:

6-fluoro-3,4-dihydronaphthalen-1(2H)-one

Downstream raw materials:

C₁₀H₁₂FN

Refernces

• 1、 -. "METALLOENZYME INHIBITOR COMPOUNDS". Page/Page column 182. . Retrieved 2018/09/28.