703-67-3

Basic information

• Product Name: 6-Fluoro-1-tetralone
• Synonyms: 6-Fluoro-1-tetralone;6-Fluoro-α-Tetralone;5-FLUORO-L-INDOMONE;6-Fluoro-3,4-dihydro-2H-naphthalen-1-one;6-FLUORTETRAL-1-ONE;6-fluoro-3;6-fluoro-3,4-dihydronaphthalen-1(2H)-one;6-fluoro-1,2,3,4-tetrahydronaphthalen-1-one
• CAS NO: 703-67-3
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• EINECS: 1312995-182-4
• Mol File: 703-67-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 269.514 °C at 760 mmHg
• Flash Point: 102.34 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Fluoro-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-1-tetralone(703-67-3)
• EPA Substance Registry System: 6-Fluoro-1-tetralone(703-67-3)

Safety Data

• Hazardous Substances Data: 703-67-3(Hazardous Substances Data)

Usage

General Description

6-Fluoro-1-tetralone is a chemical compound that belongs to the class of fluorine-containing aromatic compounds. It is used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. 6-Fluoro-1-tetralone is a pale yellow liquid with a strong, sweet, and perfumed odor. It is mainly used in organic synthesis as a building block for the production of other chemicals. Its structure consists of a six-membered aromatic ring with a fluorine atom attached to the carbon at the position 6, and a ketone functional group at position 1. 6-Fluoro-1-tetralone is considered to be a valuable intermediate for the preparation of a wide range of organic compounds.

InChI:InChI=1/C10H9FO/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h4-6H,1-3H2

Upstream product

• 3470-50-6 6-Hydroxy-1-tetralone 
• 3470-53-9 6-amino-1-tetralone 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 3470-46-0 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 149437-76-3 5-(4-fluorophenyl)-5-oxopentanoic acid 
• 455-36-7 1-(3-fluorophenyl)ethanone 
• 456-48-4 3-Fluorobenzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 127404-66-4 4-(4-fluorophenyl)but-3-enoic acid 
• 589-06-0 4-(4-fluorophenyl)butanoic acid 
• 339365-53-6 1-(4-fluorophenyl)cyclobutan-1-ol 
• 69797-47-3 4-(3-fluoro-phenyl)-4-oxo-butyric acid methyl ester 
• 62942-25-0 (3-fluorophenyl)tri-n-butyltin 

Downstream Products

• 53842-01-6 7-fluoro-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 
• 1350662-98-4 ethyl 6-fluoro-1-hydroxy-2-naphthoate 
• 75693-18-4 6-fluoro-1,2-dihydronaphthalene 
• 58472-36-9 7-fluoro-2-hydroxynaphthalene-1,4-dione 
• 1213300-76-5 (R)-(6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid methyl ester 
• 895534-22-2 (R)-(6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid 
• 895534-14-2 6-benzenesulfonyl-1,2,3,4-tetrahydro-naphthalene-1-carbonitrile 
• 895534-13-1 6-benzenesulfonyl-3,4-dihydro-naphthalene-1-carbonitrile 
• 895132-99-7 6-Benzenesulfonyl-3,4-dihydro-2H-naphthalen-1-one 
• 880544-27-4 (6-benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine 

Relevant articles and documents

Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 °C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Radical-Polar Crossover Annulation: A Platform for Accessing Polycyclic Cyclopropanes

Photoredox-mediated radical/polar crossover (RPC) processes provide unique solutions to challenging annulations. Herein, we describe an approach to the cyclopropanation of olefins that are embedded within bicyclic scaffolds. Whereas these systems are noto

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.