6-ETHYLTHIO-2,2'-BIPYRIDINE

Base Information

• Chemical Name: 6-ETHYLTHIO-2,2'-BIPYRIDINE
• CAS No.: 130897-01-7
• Molecular Formula: C12H12N2S
• Molecular Weight: 216.307
• Mol file: 130897-01-7.mol

Synonyms:6-ETHYLTHIO-2,2'-BIPYRIDINE

Chemical Property of 6-ETHYLTHIO-2,2'-BIPYRIDINE

Chemical Property:

• Boiling Point: 368.8oC at 760 mmHg
• Flash Point: 176.8oC
• PSA: 51.08000
• Density: 1.18g/cm3
• LogP: 3.25560

Purity/Quality:

6-ETHYLTHIO-2,2'-BIPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-ETHYLTHIO-2,2'-BIPYRIDINE

There total 10 articles about 6-ETHYLTHIO-2,2'-BIPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

2-bromo-6-(pyridin-2-yl)pyridine (10495-73-5) + sodium thioethylate (811-51-8) → Ethyl 6-(2,2'-pyridyl) sulfide (130897-01-7)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 4h; under 750.075 Torr; Inert atmosphere; Autoclave;

DOI:10.1039/c8tc02882f

Reference yield: 11.0%

6-ethylsulfinyl-6'-ethylthio-2,2'-bipyridine (220400-08-8) → Ethyl 6-(2,2'-pyridyl) sulfide (130897-01-7) + 6,6'''-bis(ethylthio)-2,2':6',2'':6'',2'''-quaterpyridine (220400-12-4)

Guidance literature:

With methylmagnesium bromide; In tetrahydrofuran; for 0.25h; Ambient temperature;

DOI:10.3987/COM-98-S(H)57

Reference yield:

2,6-dichloropyridine (2402-78-0) → Ethyl 6-(2,2'-pyridyl) sulfide (130897-01-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / NaH / dimethylformamide; hexamethylphosphoric acid triamide / 10 h / 0 °C

2: 73 percent / magnesium monoperoxyphthalate hexahydrate / methanol / 0.42 h / 0 °C

3: 70 percent / MeMgBr / tetrahydrofuran / 0.25 h / Ambient temperature

4: 54 percent / magnesium monoperoxyphthalate hexahydrate / methanol / 0.42 h / 0 °C

5: 11 percent / MeMgBr / tetrahydrofuran / 0.25 h / Ambient temperature

With methylmagnesium bromide; sodium hydride; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;

DOI:10.3987/COM-98-S(H)57

upstream raw materials:

2-bromo-pyridine

2-ethylsulfinyl-6-ethylthiopyridine

2-bromo-6-(pyridin-2-yl)pyridine

ethanethiol

Downstream raw materials:

2,2':6,2''-terpyridine

6-bromo-2,2':6',2''-terpyridine

Refernces

• 1、 Uenishi, Jun'ichi,Ueno, Tetsuya,Hata, Sin'ichiro,Nishiwaki, Kenji,Tanaka, Takakazu,Wakabayashi, Shoji,Yonemitsu, Osamu,Oae, Shigeru. "Coupling of consecutive pyridine ring units for oligopyridine synthesis". . p. 341 - 351. Retrieved 2007/10/03.
• 2、 Uenishi,Tanaka,Wakabayashi,Oae,Tsukube. "Ipso substitution of 2-alkylsulfinylpyridine by 2-pyridyllithium; a new preparation of oligopyridine and their bromomethyl derivatives". . p. 4625 - 4628. Retrieved 2007/10/02.