2',4',6'-Trimethylbiphenyl-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2',4',6'-Trimethylbiphenyl-4-carboxylic acid ethyl ester
CAS No.:66818-60-8
Molecular Formula:C₁₈H₂₀O₂
Molecular Weight:268.356
Hs Code.:
Mol file:66818-60-8.mol

Synonyms:2',4',6'-Trimethyl-1,1'-biphenyl-4-carboxylic acid ethyl ester;2',4',6'-Trimethylbiphenyl-4-carboxylic acid ethyl ester

Suppliers and Price of 2',4',6'-Trimethylbiphenyl-4-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2',4',6'-Trimethylbiphenyl-4-carboxylic acid ethyl ester

Chemical Property:

PSA：26.30000
LogP:4.45550

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2',4',6'-Trimethylbiphenyl-4-carboxylic acid ethyl ester

There total 12 articles about 2',4',6'-Trimethylbiphenyl-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5798-75-4
Ethyl 4-bromobenzoate

: 2,4,6-trimethylphenylmagnesium chloride

: 66818-60-8
ethyl 2',4',6'-trimethyl-[1,1'-biphenyl]-4-carboxylate

Guidance literature:: 2,4,6-trimethylphenylmagnesium chloride; With 2-iodo-propane; In tetrahydrofuran; at 25 ℃; for 0.0833333h; Inert atmosphere;

Ethyl 4-bromobenzoate; With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; In tetrahydrofuran; at 25 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1002/anie.200803730

Reference yield: 81.0%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 131379-16-3
4-(ethoxycarbonyl)phenylzinc iodide

: 66818-60-8
ethyl 2',4',6'-trimethyl-[1,1'-biphenyl]-4-carboxylate

Guidance literature:: With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 100 ℃; for 0.5h; In air;
DOI:10.1002/chem.201001201

Reference yield: 75.0%

: 576-83-0
2,4,6-trimethylphenyl bromide

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 66818-60-8
ethyl 2',4',6'-trimethyl-[1,1'-biphenyl]-4-carboxylate

Guidance literature:: 2,4,6-trimethylphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

4-iodobenzoic acid ethyl ester; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; hexane; at 60 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ja903277d