5-Benzofurancarboxamide,2,3-dihydro-(9CI)

Base Information

• Chemical Name: 5-Benzofurancarboxamide,2,3-dihydro-(9CI)
• CAS No.: 262847-54-1
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.17
• Hs Code.: 2932990090
• Mol file: 262847-54-1.mol

Synonyms:5-Benzofurancarboxamide,2,3-dihydro-(9CI);2,3-Dihydrobenzofuran-5-carboxamide

Chemical Property of 5-Benzofurancarboxamide,2,3-dihydro-(9CI)

Chemical Property:

• Boiling Point: 293.8±29.0 °C(Predicted)
• PKA: 16.45±0.20(Predicted)
• PSA: 52.32000
• Density: 1.272±0.06 g/cm3(Predicted)
• LogP: 1.42070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydrobenzofuran-5-carboxamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Benzofurancarboxamide,2,3-dihydro-(9CI)

There total 2 articles about 5-Benzofurancarboxamide,2,3-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one (151427-19-9) → 2,3-dihydrobenzofuran-5-carboxamide (262847-54-1)

Guidance literature:

With ammonia; iodine; In water; acetonitrile; at 60 ℃; for 5h;

DOI:10.1002/ejoc.201800730

Reference yield:

2.3-dihydrobenzofuran (496-16-2) → 2,3-dihydrobenzofuran-5-carboxamide (262847-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 20 h / -15 °C

2: ammonia; iodine / water; acetonitrile / 5 h / 60 °C

With aluminum (III) chloride; ammonia; iodine; In dichloromethane; water; acetonitrile; 1: |Friedel-Crafts Acylation;

DOI:10.1002/ejoc.201800730

upstream raw materials:

2-bromo-1-(2,3-dihydrobenzofuran-5-yl)ethan-1-one

2.3-dihydrobenzofuran

Refernces