ethyl 4-(benzyl(3-ethoxy-3-oxopropyl)aMino)butanoate

Base Information

• Chemical Name: ethyl 4-(benzyl(3-ethoxy-3-oxopropyl)aMino)butanoate
• CAS No.: 1164-14-3
• Molecular Formula: C18H27NO4
• Molecular Weight: 321.417
• Hs Code.: 2922509090
• Mol file: 1164-14-3.mol

Synonyms:ethyl 4-(benzyl(3-ethoxy-3-oxopropyl)aMino)butanoate;4-[(3-ethoxy-3-oxopropyl)(phenylmethyl)amino]Butanoic acid ethyl ester

Chemical Property of ethyl 4-(benzyl(3-ethoxy-3-oxopropyl)aMino)butanoate

Chemical Property:

• PSA: 55.84000
• LogP: 2.78510

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-(benzyl(3-ethoxy-3-oxopropyl)aMino)butanoate

There total 18 articles about ethyl 4-(benzyl(3-ethoxy-3-oxopropyl)aMino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 4-iodobutyrate (7425-53-8) + ethyl-3-benzylamino propionate (23583-21-3) → ethyl 4-(N-benzyl-N-(2-ethoxycarbonylethyl))aminobutyrate (1164-14-3)

Guidance literature:

With potassium carbonate; In chloroform; for 7h; Heating;

Reference yield: 59.0%

ethanol (64-17-5) + C19H24N2O4 (1619972-69-8) → ethyl 4-(N-benzyl-N-(2-ethoxycarbonylethyl))aminobutyrate (1164-14-3)

Guidance literature:

ethanol; C₁₉H₂₄N₂O₄; With potassium borohydride; at 20 - 70 ℃; for 5h; Inert atmosphere;

With ammonium hydroxide; water; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.05.081

Reference yield:

C19H24N2O4 (1619972-69-8) → ethyl 4-(N-benzyl-N-(2-ethoxycarbonylethyl))aminobutyrate (1164-14-3) + C19H26N2O4 (1619972-73-4)

Guidance literature:

With potassium borohydride; In ethanol; at 20 ℃; for 24h; Overall yield = 68 %; Overall yield = 0.013 g; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.05.081

upstream raw materials:

ethyl 4-iodobutyrate

ethyl-3-benzylamino propionate

benzylamine

ethyl acrylate

Downstream raw materials:

1-benzyl-2-pyrrolidone

1-benzylazepan-4-one

1-benzyl-1,2,3,5,6,7-hexahydroazepine-4-one hydrochloride

1-benzyl-5-bromohexahydroazepin-4-one hydrobromide