NXL 104

Base Information

Chemical Name:NXL 104
CAS No.:1192491-61-4
Molecular Formula:C7H10N3NaO6S
Molecular Weight:287.229
Hs Code.:
Mol file:1192491-61-4.mol

Synonyms:AvibactaM SodiuM Salt;NXL 104;Sulfuric Acid Mono[(1R,2S,5R)-2-(aMinocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] Ester SodiuM Salt;Avibactam (sodium);AvibactaM SodiuM NXL 104;sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate;(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide monosodium salt

Suppliers and Price of NXL 104

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AvibactamSodiumSalt
1mg
$ 60.00

DC Chemicals
Avibactamsodium >98%
100 mg
$ 300.00

DC Chemicals
Avibactamsodium >98%
250 mg
$ 600.00

DC Chemicals
Avibactamsodium >98%
1 g
$ 1200.00

Crysdot
Avibactamsodium 98+%
50mg
$ 269.00

Crysdot
Avibactamsodium 98+%
250mg
$ 747.00

Crysdot
Avibactamsodium 98+%
100mg
$ 393.00

ChemScene
Avibactam(sodium) 99.92%
200mg
$ 312.00

ChemScene
Avibactam(sodium) 99.92%
50mg
$ 156.00

ChemScene
Avibactam(sodium) 99.92%
10mg
$ 96.00

Total 130 raw suppliers

Chemical Property of NXL 104

Chemical Property:

PSA：142.44000
LogP:0.45350
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly, Sonica

Purity/Quality:

99%min, ^*data from raw suppliers

AvibactamSodiumSalt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Avibactam is a β-lactamase inhibitor (IC50s = 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively). It restores the antimicrobial activity of ceftazidime , ceftriaxone , imipenem , and piperacillin against antibiotic-resistant Enterobacteriaceae in vitro (MIC90 reduction 4-1,024-fold across 190 E. coli and K. pneumoniae clinical isolates). Formulations containing avibactam have been used to treat carbapenem-resistant Enterobacteriaceae infections.
Uses Avibactam (NXL104) is a novel β-lactamase inhibitor with a non-lactam structural scaffold. NXL104 irreversibly inhibits lactamase from Mycobacterium tuberculosis.

Technology Process of NXL 104

There total 102 articles about NXL 104 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1192651-80-1,1416134-53-6
({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt

: 1192491-61-4
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt

Guidance literature:: ({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt; With tetrafluoroboric acid; 2,2,2-trifluoroethanol;

With sodium hydrogencarbonate; at 0 ℃; for 1h;