1-ETHYL-2-METHYL-1H-INDOLE-3-CARBONITRILE

Base Information

• Chemical Name: 1-ETHYL-2-METHYL-1H-INDOLE-3-CARBONITRILE
• CAS No.: 917207-79-5
• Molecular Formula: C₁₂H₁₂N₂
• Molecular Weight: 184.241
• Hs Code.: 2933990090
• Mol file: 917207-79-5.mol

Synonyms:1-ETHYL-2-METHYL-1H-INDOLE-3-CARBONITRILE;OTAVA-BB 7020690197;1-ethyl-2-methyl-1H-indole-3-carbonitrile(SALTDATA: FREE)

Chemical Property of 1-ETHYL-2-METHYL-1H-INDOLE-3-CARBONITRILE

Chemical Property:

• Vapor Pressure: 3.86E-05mmHg at 25°C
• Boiling Point: 352.4°C at 760 mmHg
• Flash Point: 166.9°C
• PSA: 28.72000
• Density: 1.05g/cm³
• LogP: 2.84128

Purity/Quality:

97% ^*data from raw suppliers

1-ethyl-2-methyl-1H-indole-3-carbonitrile 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-ETHYL-2-METHYL-1H-INDOLE-3-CARBONITRILE

There total 5 articles about 1-ETHYL-2-METHYL-1H-INDOLE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-ethyl-2-methylindole (40876-94-6) + N?cyanosuccinimide (135205-66-2) → 1-ethyl-2-methyl-1H-indole-3-carbonitrile (917207-79-5)

Guidance literature:

With gallium(III) trichloride; In acetonitrile; at 120 ℃; for 4h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.9b00416

Reference yield: 74.0%

1-ethyl-2-methylindole (40876-94-6) + potassium ferrocyanide → 1-ethyl-2-methyl-1H-indole-3-carbonitrile (917207-79-5)

Guidance literature:

With oxygen; copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 130 ℃; for 7h;

DOI:10.1021/ol1000439

Reference yield: 65.0%

1-ethyl-2-methylindole (40876-94-6) + phenylacetonitrile (140-29-4) → 1-ethyl-2-methyl-1H-indole-3-carbonitrile (917207-79-5)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 34h;

DOI:10.1016/j.tet.2013.03.089

upstream raw materials:

1-ethyl-2-methylindole

phenylacetonitrile

N,N-dimethyl-formamide

1-ethyl-2-methyl-1H-indole-3-carboxaldehyde