4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID

Base Information

• Chemical Name: 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID
• CAS No.: 541550-00-9
• Molecular Formula: C10H8BrF3O2
• Molecular Weight: 297.072
• Hs Code.: 2914500090
• Mol file: 541550-00-9.mol

Synonyms:4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID;2-Bromo-4'-methoxy-3'-(trifluoromethoxy)acetophenone;2-Bromo-4'-methoxy-3'-(trifluoromethyl)acetophenone, 2-Bromo-1-[4-methoxy-3-(trifluoromethyl)phenyl]ethan-1-one, 5-(Bromoacetyl)-2-methoxybenzotrifluoride, 4-(Bromoacetyl)-2-(trifluoromethyl)anisole;2-Bromo-4'-methoxy-3'-(trifluoromethyl)acetophenone, 2-Bromo-1-[4-methoxy-3-(trifluoromethyl)phenyl]ethan-1-one, 5-(Bromoacetyl)-2-methoxybenzotrifluoride, 4-(Bromoacetyl)-2-(trifluo;4-Methoxy-3-(trifluoromethyl)phenacylbromide97%

Chemical Property of 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID

Chemical Property:

• PSA: 26.30000
• LogP: 3.29160

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-3-(trifluoromethyl)phenacyl bromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID

There total 1 articles about 4-METHOXY-3-(TRIFLUOROMETHYL)PHENACYL BROMID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[4-Methoxy-3-(trifluoromethyl)phenyl]ethanone (149105-10-2) → 2-bromo-1-(4-methoxy-3-(trifluoromethyl)phenyl)ethanone (541550-00-9)

Guidance literature:

With acetic acid; pyridinium hydrobromide perbromide; at 50 ℃; for 1h;

Reference yield: 30.0%

2-bromo-1-(4-methoxy-3-(trifluoromethyl)phenyl)ethanone (541550-00-9) + 2,3-methylenedioxy-9-hydroxy-10-methoxy-1,13-cycloprotoberberine chloride (1404305-70-9) → 1,2-methylenedioxy-8-(2-p-methoxy-m-trifluoromethylphenyl-2-oxoethoxy)-9-methoxycycloberberine bromide

Guidance literature:

2,3-methylenedioxy-9-hydroxy-10-methoxy-1,13-cycloprotoberberine chloride; With potassium hydroxide; In N,N-dimethyl-formamide; for 0.25h;

2-bromo-1-(4-methoxy-3-(trifluoromethyl)phenyl)ethanone; In N,N-dimethyl-formamide; at 68 - 75 ℃;

DOI:10.1021/acsmedchemlett.8b00094

Reference yield:

2-bromo-1-(4-methoxy-3-(trifluoromethyl)phenyl)ethanone (541550-00-9) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → 2-acetamido-2-[2-(4-methoxy-3-trifluoromethylphenyl)-2-oxoethyl]malonic acid diethyl ester (942399-44-2)

Guidance literature:

2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2-bromo-1-(4-methoxy-3-(trifluoromethyl)phenyl)ethanone; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

upstream raw materials:

1-[4-Methoxy-3-(trifluoromethyl)phenyl]ethanone

Downstream raw materials:

2-acetamido-2-[2-(4-methoxy-3-trifluoromethylphenyl)-2-oxoethyl]malonic acid diethyl ester