1-Boc-4-(3-Methoxypropylamino)piperidine

Base Information

• Chemical Name: 1-Boc-4-(3-Methoxypropylamino)piperidine
• CAS No.: 887588-23-0
• Molecular Formula: C14H28N2O3
• Molecular Weight: 272.388
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00656263
• Wikidata: Q82570837
• Mol file: 887588-23-0.mol

Synonyms:1-Boc-4-(3-Methoxypropylamino)piperidine;887588-23-0;tert-butyl 4-(3-methoxypropylamino)piperidine-1-carboxylate;4-(3-Methoxypropylamino)piperidine-1-carboxylic acid tert-butyl ester;TERT-BUTYL 4-((3-METHOXYPROPYL)AMINO)PIPERIDINE-1-CARBOXYLATE;TERT-BUTYL 4-[(3-METHOXYPROPYL)AMINO]PIPERIDINE-1-CARBOXYLATE;DTXSID00656263;MFCD06656634;AKOS009846624;CS-W021301;DS-2042;FT-0725404;FT-0732481;A861478

Chemical Property of 1-Boc-4-(3-Methoxypropylamino)piperidine

Chemical Property:

• Vapor Pressure: 1.77E-05mmHg at 25°C
• Boiling Point: 363.7°C at 760 mmHg
• Flash Point: 173.8°C
• PSA: 50.80000
• Density: 1.02g/cm³
• LogP: 2.34080
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 272.20999276
• Heavy Atom Count: 19
• Complexity: 268

Purity/Quality:

97% ^*data from raw suppliers

4-(3-Methoxypropylamino)piperidine-1-carboxylic acid tert-butyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)NCCCOC

Technology Process of 1-Boc-4-(3-Methoxypropylamino)piperidine

There total 1 articles about 1-Boc-4-(3-Methoxypropylamino)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 3-methoxypropylamine (5332-73-0) → 1-butoxycarbonyl-N-(3-methoxypropyl)piperidin-4-amine (887588-23-0)

Guidance literature:

palladium 10% on activated carbon; In ethanol; for 3h; under 3102.97 Torr;

Reference yield:

1-butoxycarbonyl-N-(3-methoxypropyl)piperidin-4-amine (887588-23-0) + 2,4-dichlorobenzaldeyhde (874-42-0) → 1-butoxycarbonyl-N-(3-methoxypropyl)-N-{[(2,4-dichloro)phenyl]methyl}piperidin-4-amine

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

1-butoxycarbonyl-N-(3-methoxypropyl)piperidin-4-amine (887588-23-0) + 2-Trifluoromethylbenzaldehyde (447-61-0) → 1-butoxycarbonyl-N-(3-methoxypropyl)-N-{[(2-(trifluoromethyl))phenyl]methyl}piperidin-4-amine

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

3-methoxypropylamine

Downstream raw materials:

1-butoxycarbonyl-N-(3-methoxypropyl)-N-{[(4-fluoro-2-(trifluoromethyl))phenyl]methyl}piperidin-4-amine