Methyl 6-iodonicotinate

Base Information

• Chemical Name: Methyl 6-iodonicotinate
• CAS No.: 173157-33-0
• Molecular Formula: C7H6INO2
• Molecular Weight: 263.035
• Hs Code.: 2933399090
• Mol file: 173157-33-0.mol

Synonyms:Methyl 6-iodonicotinate;6-Iodo-pyridin-3-carboxylic acid Methyl ester;Methyl 2-iodopyridine-5-carboxylate;6-Iodo-nicotinic acid Methyl ester;methyl 6-iodopyridine-3-carboxylate

Chemical Property of Methyl 6-iodonicotinate

Chemical Property:

• Boiling Point: 287.7±25.0 °C(Predicted)
• PKA: -0.19±0.10(Predicted)
• PSA: 39.19000
• Density: 1.844±0.06 g/cm3(Predicted)
• LogP: 1.47280
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%, ^*data from raw suppliers

Methyl6-iodonicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 6-iodonicotinate

There total 2 articles about Methyl 6-iodonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-iodo-nicotinic acid (13054-02-9) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 6-iodo-3-pyridinecarboxylate (173157-33-0)

Guidance literature:

In methanol; toluene; at 0 - 20 ℃; for 2h;

Reference yield:

methyl 2-<(trifluoromethyl)sulfonyl>pyridine-5-carboxylate (163276-23-1) → methyl 6-iodo-3-pyridinecarboxylate (173157-33-0)

Guidance literature:

methyl 2-<(trifluoromethyl)sulfonyl>pyridine-5-carboxylate; With hydrogenchloride; sodium iodide; In diethyl ether; toluene; at 20 - 40 ℃;

With sodium hydroxide; In diethyl ether; water; toluene; at 5 ℃; pH=10;

DOI:10.1021/jo900726f

Reference yield: 100.0%

bis(p-chlorophenyl) diselenide (20541-49-5) + methyl 6-iodo-3-pyridinecarboxylate (173157-33-0) → 6-(4-chloro-phenylselanyl)-nicotinic acid methyl ester

Guidance literature:

With polymer supported borohydride; bis(bipyridine)nickel(II) bromide; In methanol; at 60 ℃; for 16h;

DOI:10.1021/ol0058184

upstream raw materials:

6-iodo-nicotinic acid

diazomethyl-trimethyl-silane

methyl 2-<(trifluoromethyl)sulfonyl>pyridine-5-carboxylate

Downstream raw materials:

6-(hydroxy-phenyl-methyl)-nicotinic acid methyl ester

methyl 6-(trifluoromethyl)pyridine-3-carboxylate

Refernces

• 1、 -. "N-ALKYL PYRROLES AS HMG-COA REDUCTASE INHIBITORS". Page/Page column 135. . Retrieved 2010/02/12.