Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, (1R,2S,4S)- (9CI)

Base Information

• Chemical Name: Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, (1R,2S,4S)- (9CI)
• CAS No.: 208707-98-6
• Molecular Formula: C₉H₁₄O₂
• Molecular Weight: 154.209
• Mol file: 208707-98-6.mol

Synonyms:Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, (1R,2S,4S)- (9CI)

Chemical Property of Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, (1R,2S,4S)- (9CI)

Chemical Property:

• PSA: 26.30000
• LogP: 1.59560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, (1R,2S,4S)- (9CI)

There total 4 articles about Bicyclo[2.2.1]heptane-2-carboxylic acid, methyl ester, (1R,2S,4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + carbon dioxide (124-38-9,18923-20-1) + exo-2-syn-7-dichloronorbornane → 2endo-Methoxycarbonyl-norbornan (208707-98-6) + (2R,4R)-Tricyclo[2.2.1.02,6]heptane-1,3-dicarboxylic acid dimethyl ester + (1S,2S,4R)-Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid methyl ester + 3-methoxycarbonylnortricyclane + (1S,2S,4R,6R)-3-Chloro-tricyclo[2.2.1.02,6]heptane-1-carboxylic acid methyl ester

Guidance literature:

With hydrogenchloride; lithium p,p'-di-tert-butylbiphenyl radical anion; In tetrahydrofuran; diethyl ether; Product distribution; multistep reaction; 1.) -78 deg C, 5 min, 2.) 0 deg C, 1 h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + carbon dioxide (124-38-9,18923-20-1) + exo-2-chloronorbornane (765-91-3,2999-06-6,29342-53-8,36025-11-3,67844-26-2,67844-27-3,130726-60-2) → 2endo-Methoxycarbonyl-norbornan (208707-98-6) + exo-2-(methoxycarbonyl)norbornane (16646-41-6,23057-38-7,35520-81-1,61967-04-2,78392-10-6)

Guidance literature:

With hydrogenchloride; lithium p,p'-di-tert-butylbiphenyl radical anion; In diethyl ether; Product distribution; Mechanism; multistep reaction; 1.) -78 deg C, 5 min, 2.) to RT then 0 deg C;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + carbon dioxide (124-38-9,18923-20-1) + endo-2-chloronorbornane (765-91-3,2999-06-6,29342-53-8,36025-11-3,67844-26-2,67844-27-3,130726-60-2) → 2endo-Methoxycarbonyl-norbornan (208707-98-6) + exo-2-(methoxycarbonyl)norbornane (16646-41-6,23057-38-7,35520-81-1,61967-04-2,78392-10-6)

Guidance literature:

With lithium p,p'-di-tert-butylbiphenyl radical anion; In diethyl ether; Product distribution; multistep reaction; 1.) -78 deg C, 5 min, 2.) to RT then 0 deg C;

upstream raw materials:

diazomethane

carbon dioxide

exo-2-chloronorbornane

endo-2-chloronorbornane