Ethyl 4-chloro-6-nitroquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 4-chloro-6-nitroquinoline-3-carboxylate
CAS No.:103514-54-1
Molecular Formula:C12H9ClN2O4
Molecular Weight:280.66386
Hs Code.:
DSSTox Substance ID:DTXSID20540574
Wikidata:Q82416619
Mol file:103514-54-1.mol

Synonyms:ETHYL 4-CHLORO-6-NITROQUINOLINE-3-CARBOXYLATE;103514-54-1;Ethyl 4-chloro-6-nitro-quinoline-3-carboxylate;SCHEMBL538523;ETHYL4-CHLORO-6-NITROQUINOLINE-3-CARBOXYLATE;DTXSID20540574;UYLBXSAYGSUOJS-UHFFFAOYSA-N;MFCD02077676;AKOS002676266;SB71890;AS-31849;CS-0099594;4-chloro-6-nitro-quinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 4-chloro-6-nitro-, ethyl ester

Suppliers and Price of Ethyl 4-chloro-6-nitroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 13 raw suppliers

Chemical Property of Ethyl 4-chloro-6-nitroquinoline-3-carboxylate

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:280.0250845
Heavy Atom Count:19
Complexity:360

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C2C=CC(=CC2=C1Cl)[N+](=O)[O-]

Technology Process of Ethyl 4-chloro-6-nitroquinoline-3-carboxylate

There total 5 articles about Ethyl 4-chloro-6-nitroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103514-53-0
6-nitro-4-hydroxy-quinoline-3-carboxylic acid ethylester

: 103514-54-1
Ethyl 4-chloro-6-nitro-quinoline-3-carboxylate

Guidance literature:: 6-nitro-4-hydroxy-quinoline-3-carboxylic acid ethylester; With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; for 3h; Heating / reflux;

With sodium hydroxide; In chloroform; water; at 4 ℃;

Reference yield:

: 103514-53-0,175087-43-1
ethyl 6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 103514-54-1
Ethyl 4-chloro-6-nitro-quinoline-3-carboxylate

Guidance literature:: With thionyl chloride; for 17h; Reflux;
DOI:10.1016/j.ejmech.2011.01.066

Reference yield:

: 78596-42-6
ethyl α-ethoxycarbonyl-β-(4-nitroanilino)acrylate

: 103514-54-1
Ethyl 4-chloro-6-nitro-quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylether / Reflux

2: thionyl chloride / 17 h / Reflux

With thionyl chloride; In diphenylether;
DOI:10.1016/j.ejmech.2011.01.066