1-(2-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-(2-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID
• CAS No.: 886366-06-9
• Molecular Formula: C11H9F3O2
• Molecular Weight: 230.186
• Hs Code.: 2916399090
• Mol file: 886366-06-9.mol

Synonyms:1-(2-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID;1-Carboxy-(2-trifluoromethylphenyl)cyclopropane

Chemical Property of 1-(2-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

Chemical Property:

• PSA: 37.30000
• LogP: 2.82160

Purity/Quality:

97% ^*data from raw suppliers

1-(2-(Trifluoromethyl)phenyl)cyclopropanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

There total 2 articles about 1-(2-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(2-(trifluoromethyl)phenyl)cyclopropanecarbonitrile (124276-63-7) → 1-[2-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid (886366-06-9)

Guidance literature:

1-(2-(trifluoromethyl)phenyl)cyclopropanecarbonitrile; With lithium hydroxide; water; for 72h; Heating / reflux;

With hydrogenchloride; In water; at 20 ℃;

Reference yield:

2-(trifluoromethyl)phenylacetonitrile (3038-47-9) → 1-[2-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid (886366-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 16 h / 50 °C

2.1: lithium hydroxide; water / 72 h / Heating / reflux

2.2: 20 °C

With lithium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; water; In water;

Reference yield:

1-[2-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid (886366-06-9) → C11H8ClF3O

Guidance literature:

With thionyl chloride; In dichloromethane; at 22 ℃; for 14h; Inert atmosphere;

DOI:10.1002/anie.201006781

upstream raw materials:

1-(2-(trifluoromethyl)phenyl)cyclopropanecarbonitrile

2-(trifluoromethyl)phenylacetonitrile

Downstream raw materials:

(4R)-4-[(2-chlorophenyl)sulfonyl]-N-(1-cyanocyclopropyl)-1-({1-[2-(trifluoromethyl)phenyl]cyclopropyl}carbonyl)-L-prolinamide

2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone

2-oxo-2-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethyl acetate

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