2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone

Base Information

• Chemical Name: 2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone
• CAS No.: 1067188-02-6
• Molecular Formula: C₁₂H₁₀ClF₃O
• Molecular Weight: 262.659
• Mol file: 1067188-02-6.mol

Synonyms:2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone

Chemical Property of 2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone

There total 4 articles about 2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + C11H8ClF3O → 2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone (1067188-02-6)

Guidance literature:

diazomethane; C₁₁H₈ClF₃O; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 12h;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.05h;

Reference yield:

1-(2-(trifluoromethyl)phenyl)cyclopropanecarbonitrile (124276-63-7) → 2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone (1067188-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / 72 h / Heating / reflux

1.2: 20 °C

2.1: thionyl chloride / toluene / 4 h / Heating / reflux

3.1: tetrahydrofuran; diethyl ether / 12 h / 0 - 20 °C

3.2: 0.05 h / 0 °C

With lithium hydroxide; thionyl chloride; water; In tetrahydrofuran; diethyl ether; toluene;

Reference yield:

1-[2-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid (886366-06-9) → 2-chloro-1-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethanone (1067188-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / 4 h / Heating / reflux

2.1: tetrahydrofuran; diethyl ether / 12 h / 0 - 20 °C

2.2: 0.05 h / 0 °C

With thionyl chloride; In tetrahydrofuran; diethyl ether; toluene;

upstream raw materials:

diazomethane

1-(2-(trifluoromethyl)phenyl)cyclopropanecarbonitrile

1-[2-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid

2-(trifluoromethyl)phenylacetonitrile

Downstream raw materials:

2-oxo-2-(1-(2-(trifluoromethyl)phenyl)cyclopropyl)ethyl acetate