Di-tert-butyl 3,3'-Iminodipropionate

Base Information

• Chemical Name: Di-tert-butyl 3,3'-Iminodipropionate
• CAS No.: 128988-04-5
• Molecular Formula: C14H27NO4
• Molecular Weight: 273.373
• European Community (EC) Number: 805-798-1
• DSSTox Substance ID: DTXSID60449350
• Nikkaji Number: J2.142.736E
• Mol file: 128988-04-5.mol

Synonyms:128988-04-5;Di-tert-butyl 3,3'-Iminodipropionate;N-bis(tert-Butylpropionate)amine;Di-tert-butyl 3,3'-azanediyldipropanoate;tert-butyl 3-[[3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]amino]propanoate;3,3'-Iminodipropionic Acid Di-tert-butyl Ester;tert-butyl 3-{[3-(tert-butoxy)-3-oxopropyl]amino}propanoate;SCHEMBL3485766;DTXSID60449350;KCTOWZYKZDFZMQ-UHFFFAOYSA-N;MFCD07781379;di-tert-butyl-3,3'-iminodipropionate;tert-butyl 3,3'-azanediyldipropanoate;Di-tert-butyl 3,3/'-Iminodipropionate;Di-tert-butyl3,3'-azanediyldipropanoate;AS-73259;CS-0154834;D4110;T70190;3,3'-Iminobis(propionic acid tert-butyl) ester;3-(2-tert-butoxycarbonylethylamino)propionic acid tert-butyl ester;3-[[2-(tert-Butoxycarbonyl)ethyl]amino]propionic acid tert-butyl ester;beta-Alanine, N-[3-(1,1-dimethylethoxy)-3-oxopropyl]-, 1,1-dimethylethyl ester

Chemical Property of Di-tert-butyl 3,3'-Iminodipropionate

Chemical Property:

• Refractive Index: 1.4350-1.4390
• PSA: 64.63000
• LogP: 2.43050
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 273.19400834
• Heavy Atom Count: 19
• Complexity: 270

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-bis(tert-Butylpropionate)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)CCNCCC(=O)OC(C)(C)C

Technology Process of Di-tert-butyl 3,3'-Iminodipropionate

There total 4 articles about Di-tert-butyl 3,3'-Iminodipropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl 3,3‘-(benzylazanediyl)dipropanoate (377087-69-9) → di-tert-butyl 3,3’-azanediyldipropanoate (128988-04-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; water;

DOI:10.1016/j.tetlet.2005.01.026

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) → di-tert-butyl 3,3’-azanediyldipropanoate (128988-04-5)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In water;

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) → di-tert-butyl 3,3’-azanediyldipropanoate (128988-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Yb(OTf)3 / 2 h / 100 °C

2: 100 percent / H₂ / Pd(OH)2 / methanol; H₂O

With hydrogen; ytterbium(III) triflate; palladium dihydroxide; In methanol; water; 1: Michael addition reaction;

DOI:10.1016/j.tetlet.2005.01.026

upstream raw materials:

tert-Butyl acrylate

di-tert-butyl 3,3‘-(benzylazanediyl)dipropanoate

Downstream raw materials:

di-tert-butyl-N-[(2-chlorophenyl)methyl]-3,3'-iminodipropionate

3-Allyl-4-oxo-1-trityl-piperidine-3-carboxylic acid tert-butyl ester

4,5,6,7-tetrahydrothieno[3,2-c]pyridine

C₂₄H₃₆N₂O₇

Refernces

• 1、 -. "CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP". Page/Page column 190-191. . Retrieved 2020/05/19.
• 2、 -. "CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS". Page/Page column 167. . Retrieved 2018/05/27.