2-Amino-3-hydroxybenzyl alcohol

Base Information

• Chemical Name: 2-Amino-3-hydroxybenzyl alcohol
• CAS No.: 18274-82-3
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2922509090
• Mol file: 18274-82-3.mol

Synonyms:2-Amino-3-hydroxybenzyl alcohol;2-amino-3-(hydroxymethyl)phenol

Chemical Property of 2-Amino-3-hydroxybenzyl alcohol

Chemical Property:

• PSA: 66.48000
• LogP: 1.04790

Purity/Quality:

2-Amino-3-hydroxymethyl-phenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-hydroxybenzyl alcohol

There total 10 articles about 2-Amino-3-hydroxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Nitro-3-hydroxy-benzylalkohol (34112-74-8) → 2-amino-3-hydroxymethyl-phenol (18274-82-3)

Guidance literature:

With palladium on activated charcoal; hydrogen;

DOI:10.1039/c3ra41080c

Reference yield: 82.0%

3-hydroxy-2-nitrobenzaldehyde (42123-33-1) → 2-amino-3-hydroxymethyl-phenol (18274-82-3)

Guidance literature:

With sodium tetrahydroborate; C₅₄H₅₀Cl₂N₂O₃Ru₂; In ethanol; at 20 ℃; for 3h;

DOI:10.1016/j.jorganchem.2019.120984

Reference yield:

3-Carboxyphenol (99-06-9) → 2-amino-3-hydroxymethyl-phenol (18274-82-3)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / acetone

2: nitric acid / 20 °C

3: aluminum (III) chloride / dichloromethane

4: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

5: hydrogen; palladium on activated charcoal

With aluminum (III) chloride; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; nitric acid; potassium carbonate; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1039/c3ra41080c

upstream raw materials:

2-amino-3-hydroxy-benzoic acid methyl ester

methyl 3-hydroxy-2-nitrobenzoate

2-Nitro-3-hydroxy-benzylalkohol

3-Carboxyphenol

Downstream raw materials:

C₃₄H₃₂N₂O₇S

Cinnabarin

Refernces

• 1、 -. "CLASS OF NEAR INFRARED MOLECULAR PROBES FOR BIOLOGICAL APPLICATIONS". Paragraph 0098. . Retrieved 2014/10/16.