3-(Hydroxymethyl)-2-nitrophenol

Base Information

• Chemical Name: 3-(Hydroxymethyl)-2-nitrophenol
• CAS No.: 34112-74-8
• Molecular Formula: C7H7NO4
• Molecular Weight: 169.137
• Mol file: 34112-74-8.mol

Synonyms:3-(Hydroxymethyl)-2-nitrophenol;3-Hydroxy-2-nitrobenzenemethanol

Chemical Property of 3-(Hydroxymethyl)-2-nitrophenol

Chemical Property:

• Melting Point: 104 - 110 °C
• Boiling Point: 314.0±27.0 °C(Predicted)
• PKA: 6.54±0.10(Predicted)
• PSA: 86.28000
• Density: 1.489±0.06 g/cm3(Predicted)
• LogP: 1.31590

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxymethyl-2-nitro-phenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(Hydroxymethyl)-2-nitrophenol

There total 7 articles about 3-(Hydroxymethyl)-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 3-hydroxy-2-nitrobenzoate (89942-77-8) → 2-Nitro-3-hydroxy-benzylalkohol (34112-74-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/c3ra41080c

Reference yield: 61.0%

(3-methoxy-2-nitrophenyl)methanol (53055-04-2) → 2-Nitro-3-hydroxy-benzylalkohol (34112-74-8)

Guidance literature:

With aluminum (III) chloride; Reagent/catalyst;

DOI:10.1039/c3ra41080c

Reference yield:

3-Carboxyphenol (99-06-9) → 2-Nitro-3-hydroxy-benzylalkohol (34112-74-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone

2: nitric acid / 20 °C

3: aluminum (III) chloride / dichloromethane

4: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; nitric acid; potassium carbonate; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1039/c3ra41080c

upstream raw materials:

3-hydroxy-2-nitrobenzaldehyde

3-methoxy 2-nitrobenzaldehyde

3-Carboxyphenol

methyl 3-methoxybenzoate

Downstream raw materials:

2-(2-hydroxy-6-hydroxymethyl-anilino)-3,6-dioxo-5-phenoxy-cyclohexa-1,4-dienecarboxylic acid methyl ester

2-amino-3-hydroxymethyl-phenol

C₃₄H₃₂N₂O₇S

2-(tert-Butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-phenylamine