5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
• CAS No.: 75745-48-1
• Molecular Formula: C16H15ClN2O
• Molecular Weight: 286.761
• Mol file: 75745-48-1.mol

Synonyms:5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Chemical Property of 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Chemical Property:

• Melting Point: 152-155 °C(Solv: ethanol (64-17-5))
• Boiling Point: 428.1±55.0 °C(Predicted)
• PSA: 33.62000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 3.55170

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

There total 5 articles about 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4'-methoxy-4-chlorochalcone (6552-68-7,30925-57-6,41564-68-5) → 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole (75745-48-1)

Guidance literature:

With hydrazine hydrate; potassium hydroxide; In ethanol; for 24h; regioselective reaction; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2012.05.069

Reference yield:

4-chloro-4'-methoxy-chalcone (6552-68-7) → 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole (75745-48-1)

Guidance literature:

With hydrazine hydrate; for 1h; Heating;

DOI:10.1021/jo00325a014

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole (75745-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / aq. NaOH / ethanol / 2.5 h / 35 - 40 °C

2: 85percent hydrazine hydrate / 1 h / Heating

With sodium hydroxide; hydrazine hydrate; In ethanol;

DOI:10.1021/jo00325a014

upstream raw materials:

4-chloro-4'-methoxy-chalcone

4-chlorobenzaldehyde

1-(4-methoxyphenyl)ethanone

4'-methoxy-4-chlorochalcone

Downstream raw materials:

2-[5-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-4,5-dihydro-pyrazole-1-carbonyl]-benzoic acid

4,5-dihydro-3,5-bis(4-methoxyphenyl)-N-phenyl-1H-pyrazole-1-carboxamide

1-[5-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-propan-1-one

1-[5-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-2-methyl-propan-1-one