Piperidine, 1,3,4-triMethyl-4-[3-(1-Methylethoxy)phenyl]-, (3R,4R)-

Base Information

• Chemical Name: Piperidine, 1,3,4-triMethyl-4-[3-(1-Methylethoxy)phenyl]-, (3R,4R)-
• CAS No.: 143919-34-0
• Molecular Formula: C17H27NO
• Molecular Weight: 261.407
• Mol file: 143919-34-0.mol

Synonyms:Piperidine, 1,3,4-triMethyl-4-[3-(1-Methylethoxy)phenyl]-, (3R,4R)-

Chemical Property of Piperidine, 1,3,4-triMethyl-4-[3-(1-Methylethoxy)phenyl]-, (3R,4R)-

Chemical Property:

• PSA: 12.47000
• LogP: 3.64100

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidine, 1,3,4-triMethyl-4-[3-(1-Methylethoxy)phenyl]-, (3R,4R)-

There total 9 articles about Piperidine, 1,3,4-triMethyl-4-[3-(1-Methylethoxy)phenyl]-, (3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

cis-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-[3-(l-methylethoxy)phenyl]pyridine → (3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine (143919-34-0,145340-46-1,1431704-21-0)

Guidance literature:

With sodium borohydrid; sodium hydrogencarbonate; In methanol; water; ethyl acetate; acetone;

Reference yield:

(3RS,4SR)-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>pyridine → (3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine (143919-34-0,145340-46-1,1431704-21-0) + (3S,4S)-4-(3-Isopropoxy-phenyl)-1,3,4-trimethyl-piperidine (223424-24-6,145340-46-1,1431704-21-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 25 ℃; for 3h; Yield given;

DOI:10.1021/jo951403y

Reference yield:

(3R,4S)-1,2,3,4-tetrahydro-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>pyridine → (3R,5R)-1,3,4-trimethyl-4-<3-(1-methylethoxy)phenyl>piperidine (143919-34-0,145340-46-1,1431704-21-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 25 - 35 ℃;

DOI:10.13005/ojc/340246

upstream raw materials:

(R)-1,2,3,4-tetrahydro-1,3-dimethyl-4-<3-(1-methylethoxy)phenyl>pyridine

3-(isopropyloxy)phenylbromide

1,3-dimethyl-4-piperidinone

1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol

Downstream raw materials:

(3R,4R)-3,4-dimethyl-4-<3-(1-methylethoxy)phenyl>piperidinecarboxylic acid phenyl ester

ADL 08-0011

(+)-<<2'(S)-<<4(R)-3-(hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl>methyl>-1-oxo-3-phenylpropyl>amino>acetic acid 2-methylpropyl ester

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