K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

Base Information

• Chemical Name: K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine
• CAS No.: 191089-60-8
• Molecular Formula: C₃₃H₄₈N₂O₆*2ClH
• Molecular Weight: 641.676
• Mol file: 191089-60-8.mol

Synonyms:K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine;K-7174 dihydrochloride;K-7174 2HCl

Chemical Property of K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

Chemical Property:

• PSA: 61.86000
• LogP: 7.51270

Purity/Quality:

98% min ^*data from raw suppliers

K-7174 Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: K-7174, a GATA-specific inhibitor, is a putative antiinflammatory agent that attenuates effects of inflammatory cytokines in certain cell types.

Technology Process of K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine

There total 2 articles about K-7174, 1,4-Bis[5-(3,4,5-triMethoxyphenyl)-4(E)-pentenyl]hexahydro-1H-1,4-diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-enyl)-1,4-diazepane (191089-59-5) → 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-enyl)-1,4-diazepane dihydrochloride (191089-60-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃; for 3h;

DOI:10.5012/bkcs.2012.33.9.2903

Reference yield:

C14H19BrO3 → 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-enyl)-1,4-diazepane dihydrochloride (191089-60-8)

Guidance literature:

Multi-step reaction with 3 steps

1: iodine / acetonitrile / 2 h / Reflux

2: potassium carbonate; potassium iodide / acetonitrile / 7 h / Reflux

3: hydrogenchloride / 1,4-dioxane; water / 3 h / 0 - 20 °C

With hydrogenchloride; iodine; potassium carbonate; potassium iodide; In 1,4-dioxane; water; acetonitrile;

DOI:10.5012/bkcs.2012.33.9.2903

upstream raw materials:

1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-enyl)-1,4-diazepane

Refernces