C-(2-Chloro-pyriMidin-5-yl)-MethylaMine

Base Information

• Chemical Name: C-(2-Chloro-pyriMidin-5-yl)-MethylaMine
• CAS No.: 1289191-99-6
• Molecular Formula: C₅H₆ClN₃*ClH
• Molecular Weight: 180.037
• Mol file: 1289191-99-6.mol

Synonyms:C-(2-Chloro-pyriMidin-5-yl)-MethylaMine;2-Chloro-5-pyriMidineMethanaMine hydrochloride;(2-chloropyrimidin-5-yl)methanamine hydrochloride

Chemical Property of C-(2-Chloro-pyriMidin-5-yl)-MethylaMine

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

(2-chloropyrimidin-5-yl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

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Technology Process of C-(2-Chloro-pyriMidin-5-yl)-MethylaMine

There total 10 articles about C-(2-Chloro-pyriMidin-5-yl)-MethylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

tert-butyl N-tert-butoxycarbonyl-N-[(2-chloropyrimidin-5-yl)methyl] carbamate → (2-chloropyrimidin-5-yl)methanamine hydrochloride (1289191-99-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 5h;

Reference yield: 96.6%

tert-butyl N-tert-butoxycarbonyl-N-[(2-chloropyrimidin-5-yl)methyl] carbamate → (2-chloropyrimidin-5-yl)methanamine hydrochloride (1289191-99-6)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 5h;

Reference yield:

2-chloro-5-methylpyrimidine (22536-61-4) → (2-chloropyrimidin-5-yl)methanamine hydrochloride (1289191-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 18 h / 76 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 1.5 h / 0 - 20 °C

3.1: hydrogenchloride / ethyl acetate / 5 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

5-(bromomethyl)-2-chloropyrimidine

2-chloro-5-methylpyrimidine

2-chloro-5-hydroxymethyl-pyrimidine

Downstream raw materials:

C₆H₆N₄

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