2-Chloro-5-methylpyrimidine

Base Information

• Chemical Name: 2-Chloro-5-methylpyrimidine
• CAS No.: 22536-61-4
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.561
• Hs Code.: 29335990
• Mol file: 22536-61-4.mol

Synonyms:AC-248;2-chloro-5-methyl pyrimidine;5-methyl-2-chloropyrimidine;2-Chlor-5-methylpyrimidin;

Chemical Property of 2-Chloro-5-methylpyrimidine

Chemical Property:

• Vapor Pressure: 0.0628mmHg at 25°C
• Melting Point: 89-92℃
• Refractive Index: 1.529
• Boiling Point: 239.2 °C at 760 mmHg
• PKA: -1.03±0.22(Predicted)
• Flash Point: 121.5 °C
• PSA: 25.78000
• Density: 1.234 g/cm³
• LogP: 1.43840
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Uses: Used in organic synthesis, catalytic agent, petrochemical additive and synthetic chemistry. Also used as intermediate for pharmaceutical.

Technology Process of 2-Chloro-5-methylpyrimidine

There total 7 articles about 2-Chloro-5-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

2,6-dichloro-5-methylpyrimidine (1780-31-0) → 2-chloro-5-methylpyrimidine (22536-61-4)

Guidance literature:

With zinc; In water; at 95 - 105 ℃; for 5h;

Reference yield: 81.0%

trimethylaluminum (75-24-1) + 5-Bromo-2-chloropyrimidine (32779-36-5) → 2-chloro-5-methylpyrimidine (22536-61-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 24h; Heating;

DOI:10.3891/acta.chem.scand.51-0302

Reference yield:

5-methyl-2,4,6-trichloropyrimidine (1780-36-5) → 5-methylpyrimidine (2036-41-1) + 2-chloro-5-methylpyrimidine (22536-61-4)

Guidance literature:

With water; zinc;

upstream raw materials:

5-methyl-2,4,6-trichloropyrimidine

trimethylaluminum

5-Bromo-2-chloropyrimidine

water

Downstream raw materials:

5-methylpyrimidin-2-amine

3-Chloro-4-(5-methyl-pyrimidin-2-yloxy)-phenylamine

5-methyl-2-(phenyl)pyrimidine

N,N-dimethyl-2-<(5'-methylpyridinium-2'-yl)thio>ethylamine