a-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide

Base Information

Chemical Name:a-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide
CAS No.:944997-60-8
Molecular Formula:C₂₇H₃₅N₃O₂
Molecular Weight:433.594
Hs Code.:

Synonyms:a-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide;Benzeneacetamide,α-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-;C3A Receptor Agonist

Suppliers and Price of a-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of a-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of a-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide

There total 7 articles about a-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 944997-60-8
α-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]benzeneacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / P(o-Tol)3 / Pd(OAc)2 / dimethylformamide / 80 °C

2: H₂ / Pd/C / methanol

3: NaOH / methanol

4: EDCI; HOBt; Et₃N / CH₂Cl₂

With sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1016/j.bmcl.2007.04.023

Reference yield:

: 81124-48-3
methyl (E)-3-(3-pyridyl)acrylate

: 944997-60-8
α-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]benzeneacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol

2: NaOH / methanol

3: EDCI; HOBt; Et₃N / CH₂Cl₂

With sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.04.023

Reference yield:

: 103-82-2
phenylacetic acid

: 944997-60-8
α-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]benzeneacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran / -70 - -20 °C

2: EDCI; HOBt / dimethylformamide

With n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.04.023