4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid pinacol ester

Base Information

• Chemical Name: 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid pinacol ester
• CAS No.: 914610-39-2
• Molecular Formula: C17H27BN2O4S
• Molecular Weight: 366.289
• Hs Code.: 2934999090
• Mol file: 914610-39-2.mol

Synonyms:4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid pinacol ester;4-(4-Methylhomopiperazin-1-ylsulfonyl)phenylboronic acid pinacol ester;1-Methyl-4-[4-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-benzenesulfonyl]-piperazine;1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfonyl)piperazine

Chemical Property of 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid pinacol ester

Chemical Property:

• PSA: 67.46000
• LogP: 1.87850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid pinacol ester

There total 7 articles about 4-(4-Methylpiperazin-1-ylsulfonyl)phenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-((4-bromophenyl)sulfonyl)-4-methylpiperazine (837-12-7) + bis(pinacol)diborane (73183-34-3) → 1-methyl-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine (914610-39-2)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; Inert atmosphere; Reflux;

Reference yield:

1-((4-bromophenyl)sulfonyl)-4-methylpiperazine (837-12-7) → 1-methyl-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine (914610-39-2)

Guidance literature:

With potassium acetate; bis(pinacol)diborane; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 90 ℃; for 24h;

Reference yield:

1-((4-bromophenyl)sulfonyl)-4-methylpiperazine (837-12-7) + bis(pinacol)diborane (73183-34-3) → 1-methyl-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine (914610-39-2) + C22H30N4O4S2

Guidance literature:

With potassium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 4h; Inert atmosphere;

upstream raw materials:

1-((4-bromophenyl)sulfonyl)-4-methylpiperazine

bis(pinacol)diborane

4-bromobenzenesulfonyl chloride

1-methyl-piperazine

Downstream raw materials:

(S)-tert-butyl 4-(1-amino-3-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate