4-(2-BROMOPROPANOYL)MORPHOLINE

Base Information

• Chemical Name: 4-(2-BROMOPROPANOYL)MORPHOLINE
• CAS No.: 2620-13-5
• Molecular Formula: C7H12BrNO2
• Molecular Weight: 222.082
• Hs Code.: 2934999090
• Mol file: 2620-13-5.mol

Synonyms:4-(2-BROMOPROPANOYL)MORPHOLINE

Chemical Property of 4-(2-BROMOPROPANOYL)MORPHOLINE

Chemical Property:

• PSA: 29.54000
• LogP: 0.56650

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Bromopropanoyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-BROMOPROPANOYL)MORPHOLINE

There total 2 articles about 4-(2-BROMOPROPANOYL)MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + α-bromopropionyl bromide (563-76-8) → α-bromomorpholinopropanamide (2620-13-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1021/jacs.1c07726

Reference yield: 78.0%

morpholine (110-91-8,99108-56-2) + 2-Bromopropionyl chloride (7148-74-5) → α-bromomorpholinopropanamide (2620-13-5)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1002/anie.201611024

Reference yield: 99.0%

S,S-diphenylsulphoximine (22731-83-5) + α-bromomorpholinopropanamide (2620-13-5) → (R)-((1-morpholino-1-oxopropan-2-yl)imino)diphenyl-λ6-sulfanone

Guidance literature:

With copper(II) hexafluoro-2,4-pentanedionate; C₉₅H₁₁₈N₃O₂P; caesium carbonate; In diethyl ether; at 20 ℃; for 72h; enantioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.1c07726

upstream raw materials:

morpholine

α-bromopropionyl bromide

2-Bromopropionyl chloride

Downstream raw materials:

4-[N-(2,6-dimethyl-phenyl)-alanyl]-morpholine

N,N-diisopropyl-3-methyl-4-morpholin-4-yl-4-oxo-2-phenyl-butyramide

4-[N-(4-benzyloxy-phenyl)-alanyl]-morpholine

4-[N-(5-acetyl-2-propoxy-phenyl)-alanyl]-morpholine

Refernces

• 1、 Devannah, Vijayarajan,Sharma, Rajgopal,Watson, Donald A.. "Nickel-Catalyzed Asymmetric C-Alkylation of Nitroalkanes: Synthesis of Enantioenriched β-Nitroamides". supporting information. p. 8436 - 8440. Retrieved 2019/06/13.
• 2、 -. "Based on 2- halogen propionyl chloride method of synthesizing acryloyl morpholine (by machine translation)". Paragraph 0038; 0039. . Retrieved 2017/03/14.