IDX-184

Base Information

• Chemical Name: IDX-184
• CAS No.: 1036915-08-8
• Molecular Formula: C25H35N6O9PS
• Molecular Weight: 626.627
• Mol file: 1036915-08-8.mol

Synonyms:IDX-184;2'-C-Methylguanosine 5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]

Chemical Property of IDX-184

Chemical Property:

• Density: 1.59

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IDX-184

There total 5 articles about IDX-184 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate] (1036915-07-7) → IDX 184 (1036915-08-8)

Guidance literature:

With ethanol; acetyl chloride; In acetonitrile; at 25 ℃; for 11.5h; Large scale;

DOI:10.1021/op5003837

Reference yield: 6.0%

→ IDX 184 (1036915-08-8)

Guidance literature:

Reference yield:

2'-C-methylguanosine-2',3'-O-phenylboronate → IDX 184 (1036915-08-8)

Guidance literature:

Multi-step reaction with 4 steps

1: pivaloyl chloride; pyridine / acetonitrile / 5 h / 8 - 17 °C / Large scale

2: tetrachloromethane / acetonitrile / 6 h / 8 - 10 °C / Large scale

3: citric acid / water; acetonitrile; tert-butyl methyl ether / 1 h / 25 °C / Large scale

4: acetyl chloride; ethanol / acetonitrile / 11.5 h / 25 °C / Large scale

With pyridine; tetrachloromethane; ethanol; pivaloyl chloride; acetyl chloride; citric acid; In tert-butyl methyl ether; water; acetonitrile; 2: |Atherton-Todd Synthesis;

DOI:10.1021/op5003837

upstream raw materials:

2'-C-methylguanosine

2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]

Downstream raw materials:

C₂₄H₃₃N₆O₉P

C₁₈H₂₃N₆O₇P