2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]

Base Information

• Chemical Name: 2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]
• CAS No.: 1036915-07-7
• Molecular Formula: C₄₄H₄₉N₆O₉PS
• Molecular Weight: 868.948
• Mol file: 1036915-07-7.mol

Synonyms:2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]

Chemical Property of 2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]

There total 5 articles about 2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C37H42N5O9PS (1036915-06-6) + benzylamine (100-46-9) → 2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate] (1036915-07-7)

Guidance literature:

In tetrachloromethane; at 20 ℃; for 1h;

Reference yield: 85.0%

C50H52BN6O9PS → 2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate] (1036915-07-7)

Guidance literature:

With citric acid; In tert-butyl methyl ether; water; acetonitrile; at 25 ℃; for 1h; Large scale;

DOI:10.1021/op5003837

Reference yield:

2'-C-methylguanosine-2',3'-O-phenylboronate → 2'-C-methylguanosine-5'-[2-[(3-trityloxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate] (1036915-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pivaloyl chloride; pyridine / acetonitrile / 5 h / 8 - 17 °C / Large scale

2: tetrachloromethane / acetonitrile / 6 h / 8 - 10 °C / Large scale

3: citric acid / water; acetonitrile; tert-butyl methyl ether / 1 h / 25 °C / Large scale

With pyridine; tetrachloromethane; pivaloyl chloride; citric acid; In tert-butyl methyl ether; water; acetonitrile; 2: |Atherton-Todd Synthesis;

DOI:10.1021/op5003837

upstream raw materials:

C₃₇H₄₂N₅O₉PS

benzylamine

2'-C-methylguanosine

Downstream raw materials:

C₄₅H₄₇N₆O₁₀PS

IDX 184

2'-C-methylguanosine-5'-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate]

2’-C-methyl-guanosine 5’-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl N-(phenylmethyl)phosphoramidate]