Ethanone, 1-[4-bromo-1-(dimethylamino)-2-naphthalenyl]-2-chloro-2,2-difluoro-

Base Information

• Chemical Name: Ethanone, 1-[4-bromo-1-(dimethylamino)-2-naphthalenyl]-2-chloro-2,2-difluoro-
• CAS No.: 353457-09-7
• Molecular Formula: C14H11BrClF2NO
• Molecular Weight: 0
• Mol file: 353457-09-7.mol

Synonyms:Ethanone, 1-[4-bromo-1-(dimethylamino)-2-naphthalenyl]-2-chloro-2,2-difluoro-

Chemical Property of Ethanone, 1-[4-bromo-1-(dimethylamino)-2-naphthalenyl]-2-chloro-2,2-difluoro-

Chemical Property:

• PSA: 20.31000
• LogP: 4.68260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[4-bromo-1-(dimethylamino)-2-naphthalenyl]-2-chloro-2,2-difluoro-

There total 1 articles about Ethanone, 1-[4-bromo-1-(dimethylamino)-2-naphthalenyl]-2-chloro-2,2-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

chlorodifluoroacetic anhydride (2834-23-3) + 4-bromo-1-(N,N-dimethylamino)naphthalene (59557-93-6) → N,N-dimethyl-2-chlorodifluoroacetyl-4-bromo-1-naphthylamine (353457-09-7)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 18h;

DOI:10.1055/s-2001-14594

Reference yield: 62.0%

4-fluorobenzaldehyde (459-57-4) + N,N-dimethyl-2-chlorodifluoroacetyl-4-bromo-1-naphthylamine (353457-09-7) → 1-(4-bromo-1-dimethylamino-naphthalen-2-yl)-2,2-difluoro-3-(4-fluoro-phenyl)-3-hydroxy-propan-1-one

Guidance literature:

With Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 3h;

DOI:10.1055/s-2001-14594

Reference yield: 45.0%

benzaldehyde (100-52-7) + N,N-dimethyl-2-chlorodifluoroacetyl-4-bromo-1-naphthylamine (353457-09-7) → 1-(4-Bromo-1-dimethylamino-2-naphthyl)-2,2-difluoro-3-hydroxy-3-phenyl-propan-1-one

Guidance literature:

With Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 3h;

DOI:10.1055/s-2001-14594

upstream raw materials:

chlorodifluoroacetic anhydride

4-bromo-1-(N,N-dimethylamino)naphthalene

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