cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

Base Information

Chemical Name:cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide
CAS No.:1142943-96-1
Molecular Formula:C10H9BrN4O
Molecular Weight:281.112
Hs Code.:
Mol file:1142943-96-1.mol

Synonyms:cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide;filgotinib intermediate;N-(5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

Suppliers and Price of cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide 97%
1g
$ 681.00

Ambeed
N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide 98%
5g
$ 235.00

Ambeed
N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide 98%
1g
$ 68.00

Ambeed
N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide 98%
250mg
$ 26.00

Ambeed
N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide 98%
100mg
$ 15.00

Alichem
N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
1g
$ 731.24

AK Scientific
N-(5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
5g
$ 606.00

Total 33 raw suppliers

Chemical Property of cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

Chemical Property:

PKA:7.68±0.20(Predicted)
PSA：59.29000
Density:1.96±0.1 g/cm3(Predicted)
LogP:1.91330

Purity/Quality:

99%, ^*data from raw suppliers

N-(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

There total 6 articles about cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.8%

: 1010120-55-4
5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1142943-96-1
cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

Guidance literature:: 5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine; With triethylamine; In dichloromethane; at -20 - 0 ℃; for 0.5h;

cyclopropanecarboxylic acid chloride; In dichloromethane; at 20 ℃;

With ammonium hydroxide; In methanol; at 20 ℃; for 1h;

Reference yield:

: N-(5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-N-(cyclopropanecarbonyl)cyclopropanecarboxamide

: 1142943-96-1
cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

Guidance literature:: With methanol; potassium carbonate; at 20 ℃; for 1h;

Reference yield:

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 1142943-96-1
cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 24.25 h / 5 - 50 °C

2.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol / 4 h / 20 °C / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dmap / acetonitrile / 18 h / 80 °C

3.2: 2 h / 20 °C

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; dmap; In methanol; ethanol; ethyl acetate; acetonitrile;