5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Base Information

• Chemical Name: 5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
• CAS No.: 1010120-55-4
• Molecular Formula: C6H5BrN4
• Molecular Weight: 213.037
• Hs Code.: 2933998090
• Mol file: 1010120-55-4.mol

Synonyms:(5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amine;

Chemical Property of 5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Chemical Property:

• PKA: 3.99±0.30(Predicted)
• PSA: 56.21000
• Density: 2.09
• LogP: 1.65520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.9% ^*data from raw suppliers

5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

There total 5 articles about 5-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) → 5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine (1010120-55-4)

Guidance literature:

2-Amino-6-bromopyridine; With Ethoxycarbonyl isothiocyanate; In dichloromethane; at 20 ℃;

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol;

DOI:10.1039/c8ce00423d

Reference yield: 92.8%

ethyl N-[(6-bromopyridin-2-yl)carbamothioyl]carbamate (1010120-59-8) → 5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine (1010120-55-4)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In ethanol; at 70 - 100 ℃; for 3h;

Reference yield: 85.1%

ethyl-N-[(6-bromo-2-pyridyl)thiocarbamoyl]carbamic acid → 5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine (1010120-55-4)

Guidance literature:

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; at 25 - 80 ℃; for 4h; Inert atmosphere;

upstream raw materials:

ethyl N-[(6-bromopyridin-2-yl)carbamothioyl]carbamate

2-Amino-6-bromopyridine

Downstream raw materials:

5-(3-chlorophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine

cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

5-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

(5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-(4-nitro-phenyl)-amine