N3-ethylpyridine-3,4-diamine

Base Information

• Chemical Name: N3-ethylpyridine-3,4-diamine
• CAS No.: 61719-62-8
• Molecular Formula: C7H11N3
• Molecular Weight: 137.18
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10468379
• Wikidata: Q82295552
• Mol file: 61719-62-8.mol

Synonyms:N3-ethylpyridine-3,4-diamine;61719-62-8;3,4-Pyridinediamine, N3-ethyl-;3-N-ethylpyridine-3,4-diamine;4-amino-3-ethylaminopyridine;N3-ethyl-3,4-Pyridinediamine;N-Ethyl-pyridine-3,4-diamine;SCHEMBL2268998;N3-Ethyl-pyridine-3,4-diamine;AMY4879;DTXSID10468379;RUFZKKRVKYJHJM-UHFFFAOYSA-N;MFCD11114582;AKOS006306441;SB52716;BS-29221;A8550

Chemical Property of N3-ethylpyridine-3,4-diamine

Chemical Property:

• PSA: 51.67000
• LogP: 1.09870
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 137.095297364
• Heavy Atom Count: 10
• Complexity: 94.9

Purity/Quality:

98%Min ^*data from raw suppliers

N3-Ethylpyridine-3,4-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC1=C(C=CN=C1)N

Technology Process of N3-ethylpyridine-3,4-diamine

There total 10 articles about N3-ethylpyridine-3,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-(4-aminopyridin-3-yl)acetamide hydrochloride (676464-96-3) → N-3-ethyl-pyridine-3,4-diamine (61719-62-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 25 ℃; for 16h; Inert atmosphere;

DOI:10.1021/op0502250

Reference yield: 51.0%

3-ethylamino-4-nitropyridine N-oxide (14043-25-5) → N-3-ethyl-pyridine-3,4-diamine (61719-62-8)

Guidance literature:

3-ethylamino-4-nitropyridine N-oxide; With iron; acetic acid; at 80 ℃; for 4h;

With methanol; ammonia;

Reference yield:

3-chloro-4-nitropyridine N-oxide (76439-45-7) + ethylamine (75-04-7,85404-22-4) → 3-ethylamino-4-nitro-3-pyridine N-oxide + N-3-ethyl-pyridine-3,4-diamine (61719-62-8)

Guidance literature:

In tetrahydrofuran; ethanol;

upstream raw materials:

ethyl-(4-nitro-pyridin-3-yl)-amine

N-(4-aminopyridin-3-yl)acetamide hydrochloride

3-ethylamino-4-nitropyridine N-oxide

3-chloro-4-nitropyridine N-oxide

Downstream raw materials:

3-ethyl-3H-imidazo<4,5-c>pyridine

2-chloromethyl-3-ethyl-3H-imidazo[4,5-c]pyridine

2-chloromethyl-3-ethyl-3H-imidazo[4,5-c]pyridine hydrochloride

3-ethyl-2-(2-thiazol-2-yl-imidazol-1-ylmethyl)-3H-imidazo[4,5-c]pyridine

Refernces

• 1、 Caron, Stephane,Do, Nga M.,McDermott, Ruth E.,Bahmanyar. "Regioselective synthesis of an imidazo[4,5-c]pyridine through selective acylation of 3,4-diaminopyridine: Synthesis of CP-885,316". . p. 257 - 261. Retrieved 2012/12/22.
• 2、 -. "Process for preparing haloalkyl pyrimidines". Page 8. . Retrieved 2008/06/13.