5-Fluoro-3-(4-hydroxybutyl)-1,3-dihydroindol-2-one

Base Information

Chemical Name:5-Fluoro-3-(4-hydroxybutyl)-1,3-dihydroindol-2-one
CAS No.:637341-60-7
Molecular Formula:C₁₂H₁₄FNO₂
Molecular Weight:223.247
Hs Code.:2933790090
DSSTox Substance ID:DTXSID30378128
Nikkaji Number:J2.009.976C
Mol file:637341-60-7.mol

Synonyms:637341-60-7;5-fluoro-3-(4-hydroxybutyl)-1,3-dihydroindol-2-one;5-fluoro-3-(4-hydroxybutyl)indolin-2-one;5-FLUORO-3-(4-HYDROXY-BUTYL)-1,3-DIHYDRO-INDOL-2-ONE;MFCD06245572;5-fluoro-3-(4-hydroxybutyl)-2,3-dihydro-1H-indol-2-one;5-Fluoro-3-(4-hydroxybutyl)-2-oxindole;5-Fluoro-3-(4-hydroxybut-1-yl)-1,3-dihydroindol-2-one;SCHEMBL1455904;DTXSID30378128;AKOS005257249;A834489;3-(4-Hydroxybutyl)-5-fluoro-1,3-dihydro-2H-indole-2-one;5-fluoranyl-3-(4-oxidanylbutyl)-1,3-dihydroindol-2-one;5-fluoro-3-(4-hydroxybutyl)-1,3-dihydro-2h-indol-2-one

Suppliers and Price of 5-Fluoro-3-(4-hydroxybutyl)-1,3-dihydroindol-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
5-Fluoro-3-(4-hydroxybutyl)-2-oxindole
50 mg
$ 344.00

Apolloscientific
5-Fluoro-3-(4-hydroxybut-1-yl)-2-oxindole
50mg
$ 215.00

American Custom Chemicals Corporation
5-FLUORO-3-(4-HYDROXY-BUTYL)-1,3-DIHYDRO-INDOL-2-ONE 95.00%
50MG
$ 890.39

Total 8 raw suppliers

Chemical Property of 5-Fluoro-3-(4-hydroxybutyl)-1,3-dihydroindol-2-one

Chemical Property:

Vapor Pressure:3.68E-06mmHg at 25°C
Melting Point:130-131 °C(Solv: ethyl acetate (141-78-6); heptane (142-82-5))
Boiling Point:371°C at 760 mmHg
PKA:12.96±0.40(Predicted)
Flash Point:178.2°C
PSA：49.33000
Density:1.217g/cm³
LogP:2.16200
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:223.10085685
Heavy Atom Count:16
Complexity:259

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-3-(4-hydroxybutyl)-2-oxindole ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1F)C(C(=O)N2)CCCCO

Technology Process of 5-Fluoro-3-(4-hydroxybutyl)-1,3-dihydroindol-2-one

There total 1 articles about 5-Fluoro-3-(4-hydroxybutyl)-1,3-dihydroindol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 110-63-4
Butane-1,4-diol

: 637341-60-7
5-fluoro-3-(4-hydroxybutyl)-1,3-dihydro-2H-indol-2-one

Guidance literature:: With hydrogen; nickel; at 190 ℃; for 8h; under 11250.9 Torr;
DOI:10.1002/ejoc.200300219

Reference yield:

: 637341-60-7
5-fluoro-3-(4-hydroxybutyl)-1,3-dihydro-2H-indol-2-one

: 5-fluoro-3-[4-(4-phenylpiperazin-1-yl)butyl]-1,3-dihydro-2H-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / -78 - 20 °C

2: sodium carbonate / 1 h / 120 °C

With sodium carbonate; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm200547z

Reference yield:

: 637341-60-7
5-fluoro-3-(4-hydroxybutyl)-1,3-dihydro-2H-indol-2-one

: 5-fluoro-3-(4-{4-[3-(trifluoromethyl)phenyl]-3,6-dihydropyridin-1(2H)-yl}butyl)-1,3-dihydro-2H-indol-2-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / -78 - 20 °C

2: sodium carbonate / 1 h / 120 °C

With sodium carbonate; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm200547z