110-63-4

Basic information

• Product Name: 1,4-Butanediol
• Synonyms: 1,4-Butyleneglycol;1,4-Dihydroxybutane;1,4-Tetramethylene glycol;DabcoDBO;Diol 14B;NSC 406696;Polycure D;Sucol B;Tetramethylene 1,4-diol;Tetramethylene glycol;Vibracure A 250;ZM 0025
• CAS NO: 110-63-4
• Molecular Formula: C₄H₁₀O₂
• Molecular Weight: 90.121
• EINECS: 203-786-5
• Mol File: 110-63-4.mol
• Article Data: 395

Chemical Properties

• Melting Point: 20℃
• Boiling Point: 227.999 °C at 760 mmHg
• Flash Point: 105.909 °C
• Appearance: viscous colourless liquid
• Density: 1.006 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.441
• PKA: 14.73±0.10(Predicted)
• Water Solubility: Miscible
• CAS DataBase Reference: 1,4-Butanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Butanediol(110-63-4)
• EPA Substance Registry System: 1,4-Butanediol(110-63-4)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:
• Hazardous Substances Data: 110-63-4(Hazardous Substances Data)

Usage

General Description

1,4-Butanediol (BDO) is an organic compound classified as a glycol and is mainly used in the production of polymers and plastics. It is a colorless, viscous liquid at standard temperature and pressure, soluble in water and many organic solvents. BDO is primarily used as a monomer in producing polybutylene terephthalate (PBT), a thermoplastic polymer, commonly used in electronic products. It is also used in other polymer resins and for the production of spandex. Despite its application in industrial uses, it can be harmful if inhaled, swallowed, or absorbed through the skin, posing potential health hazards.

InChI:InChI=1/C4H10O2/c5-3-1-2-4-6/h5-6H,1-4H2

Synthetic route

succinic acid diethyl ester (123-25-1) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With C56H70Cl3N10Ru2(1+)*F6P(1-); potassium tert-butylate; hydrogen In tetrahydrofuran; dodecane at 70℃; under 37503.8 Torr; for 16h; Inert atmosphere; Glovebox; Autoclave;	100%
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 15h; Glovebox; Autoclave;	91%
With ethanol; sodium

4-butanolide (96-48-0) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With sodium aluminum tetrahydride In tetrahydrofuran at 0℃; for 0.0833333h;	100%
With C31H33ClN2O3RuS; potassium tert-butylate; hydrogen In isopropyl alcohol at 60℃; under 37503.8 Torr; for 48h; Inert atmosphere;	100%
With C39H39N6ORu(1+)*Br(1-); potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 37503.8 Torr; for 16h; Reagent/catalyst;	100%

succinic acid anhydride (108-30-5) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With sodium aluminum tetrahydride In tetrahydrofuran for 24h; Ambient temperature;	100%
With hydrogen In water at 155℃; under 165017 Torr; Reagent/catalyst;	95%
With sodium tetrahydroborate; C36H30F6N10Ni4O10(2+)*2C2F3O2(1-); zinc(II) chloride In tetrahydrofuran at 45℃; for 12h;	78%
With [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)]; hydrogen In 1,4-dioxane at 195℃; under 37503.8 Torr; for 24h; Autoclave; Inert atmosphere;
With C38H54Cl2N2P2Ru; hydrogen; sodium hydride In toluene at 160 - 190℃; under 60006 Torr; for 23h; Autoclave; Sealed tube;	98 %Spectr.

maleic acid (110-16-7) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With hydrogen In water	100%
With hydrogen In water	100%
With hydrogen In water	100%

oxirane (75-21-8) + (naphthalene)Yb(THF)3 → naphthalene (91-20-3) + Butane-1,4-diol (110-63-4) + ytterbium hydroxide

Conditions	Yield
With hydrogen cation In tetrahydrofuran shaken for 10 min at room temp.; centrifuged, decanted, soln. contains naphthalene, pptn. hydrolysed in THF: butanediol detd. by GLC in the organic layer and a pptn. (Yb(OH)3);	A 83% B 100% C 75%

1,4-dihydroxybut-2-yne (110-65-6) → Butane-1,4-diol (110-63-4) + 1,4-butenediol (6117-80-2)

Conditions	Yield
With hydrogen; copper-palladium; silica gel In ethanol at 25℃; under 760 Torr; Kinetics;	A n/a B 99%
With LaNi5 hydride In tetrahydrofuran; methanol at 0℃; for 6h;	A 10% B 67%

4-hydroxybutyl (4-oxo-3-phenyl-4H-thiochromen-2-yl)methylcarbonate (1033736-93-4) → Butane-1,4-diol (110-63-4) + carbon dioxide (124-38-9) + C16H10O3S (1033736-87-6)

Conditions	Yield
In d(4)-methanol at 20℃; for 1h; Conversion of starting material; light irradiation;	A 99% B n/a C 85%

maleic acid (110-16-7) → tetrahydrofuran (109-99-9) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + succinic acid (110-15-6) + acetic acid (64-19-7)

Conditions	Yield
With hydrogen; 0.5 percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity;	A 0.37% B 0.28% C 0.37% D 98.89% E 0.08%

maleic acid (110-16-7) → tetrahydrofuran (109-99-9) + 4-butanolide (96-48-0) + methanol (67-56-1) + Butane-1,4-diol (110-63-4) + malic acid (617-48-1) + succinic acid (110-15-6) + acetic acid (64-19-7) + butan-1-ol (71-36-3)

Conditions	Yield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity;	A 0.45% B 0.06% C 0% D 0.21% E 0.36% F 98.73% G 0.04% H 0.08%

...Expand

1,4-dihydroxybut-2-yne (110-65-6) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With hydrogen; Ni catalyst as described in example 1 of U.S. Pat. No. 5,068,468 at 140℃; under 150015 Torr; for 336h; Conversion of starting material;	98.3%
With hydrogen; Ni catalyst as described in example 1 of U.S. Pat. No. 5,068,468 In water at 140℃; under 150015 Torr; for 24 - 336h; Product distribution / selectivity;	98.3%
With hydrogen In water at 100 - 135℃; under 60006 Torr; for 6h; Reagent/catalyst; Temperature; Pressure;	90%

maleic acid (110-16-7) → tetrahydrofuran (109-99-9) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + 4-hydroxybutanoic acid (591-81-1) + succinic acid (110-15-6) + acetic acid (64-19-7) + butan-1-ol (71-36-3)

Conditions	Yield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity;	A 0.77% B 0.38% C 0.24% D 0.05% E 98.28% F 0.02% G 0.26%

1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-butane (122795-01-1) → Butane-1,4-diol (110-63-4)

Conditions	Yield
sulfated SnO2 In methanol at 20℃; for 0.166667h;	98%
With sodium hydride In N,N,N,N,N,N-hexamethylphosphoric triamide at 25℃; for 12h;	70%

dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → tetrahydrofuran (109-99-9) + 2-methoxytetrahydrofuran (13436-45-8) + 4-butanolide (96-48-0) + propan-1-ol (71-23-8) + 2-(4'-hydroxybutoxy)-tetrahydrofuran (64001-06-5) + Butane-1,4-diol (110-63-4) + butan-1-ol (71-36-3)

Conditions	Yield
With hydrogen; copper catalyst, T 4489, Sud-Chemie AG, Munich at 150 - 280℃; under 187519 Torr; Neat liquid(s) and gas(es)/vapour(s);	A 1% B n/a C 0.4% D n/a E n/a F 98% G 0.5%

Dimethyl succinate (106-65-0) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 38002.6 Torr; for 6h; Autoclave;	97%
With C13H34BFeNOP2; hydrogen In tetrahydrofuran at 100℃; under 22502.3 Torr; for 18h; Autoclave; Inert atmosphere;	97%
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 37503.8 Torr; for 6h;	97%

succinic acid (110-15-6) → 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4)

Conditions	Yield
With C36H54IrN2P2(1+)*C24H20B(1-); hydrogen; sodium hydride In toluene at 180℃; under 7500.75 - 45004.5 Torr; for 18h; Reagent/catalyst; Temperature; Pressure; Autoclave; Sealed tube;	A 5% B 95%
Stage #1: succinic acid In 1,4-dioxane at 500℃; for 4h; Stage #2: With hydrogen In 1,4-dioxane at 200℃; under 60006 Torr; for 5h; Catalytic behavior; Reagent/catalyst;	A n/a B 64.7%
With hydrogen In water at 130℃; under 37503.8 Torr; for 12h; Pressure; Reagent/catalyst; Temperature; Autoclave;	A 34% B 23%

succinic acid (110-15-6) → Butane-1,4-diol (110-63-4) + butan-1-ol (71-36-3)

Conditions	Yield
With perrhenic acid anhydride; hydrogen In 1,4-dioxane at 209.84℃; under 187519 Torr; for 4h; Catalytic behavior; Autoclave; Overall yield = 100 %;	A 94% B 6%
With hydrogen In water at 130℃; under 37503.8 Torr; for 12h; Pressure; Reagent/catalyst; Temperature; Autoclave;	A 92% B 5%
With hydrogen In water at 99.84℃; under 45004.5 Torr;

1-(phenylmethyl)-2,5-pyrrolidinedione (2142-06-5) → Butane-1,4-diol (110-63-4) + benzylamine (100-46-9)

Conditions	Yield
With C25H19BrMnN2O2P; potassium tert-butylate; hydrogen In tetrahydrofuran at 130℃; under 22502.3 Torr; for 48h; Inert atmosphere; Glovebox; Autoclave; Green chemistry;	A 85% B 93%
With [Ru(PtBuNNHtBu)H(CO)Cl]; potassium tert-butylate; hydrogen In 1,4-dioxane at 135℃; under 30003 Torr; for 40h; Autoclave;

1-tert-butyldimethylsilyloxy-4-triethylsilyloxybutane (117785-64-5) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With H-Y zeolite In methanol for 4h; Ambient temperature;	92%

1,4-butenediol (821-11-4, 6117-80-2, 110-64-5) + 2-phenyl-1,3,2-benzodioxaborole (5747-23-9) → Butane-1,4-diol (110-63-4) + phenol (108-95-2)

Conditions	Yield
With oxygen; hydrazine hydrate In acetonitrile at 32℃; under 760.051 Torr; for 4h; Schlenk technique;	A 92% B 90%

maleic acid (110-16-7) → tetrahydrofuran (109-99-9) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + 4-hydroxybutanoic acid (591-81-1) + malic acid (617-48-1) + succinic acid (110-15-6) + acetic acid (64-19-7)

Conditions	Yield
With hydrogen; 0.5percent Pd/2.0percent Re on Rutile TiO2 at 110℃; Product distribution / selectivity;	A 1.27% B 4.78% C 1.55% D 1.24% E 0.48% F 90.6% G 0.08%

1-(tert-Butyl-dimethyl-silanyloxy)-4-triisopropylsilanyloxy-butane → Butane-1,4-diol (110-63-4) + 4-((triisopropylsilyl)oxy)butan-1-ol (175849-51-1)

Conditions	Yield
With iron(III) chloride In methanol at 23℃; for 4h;	A 4% B 90%

cis-1,4-anhydroerythritol (4358-64-9) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With water; hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 4h; Reagent/catalyst; Solvent;	90%
With cerium(IV) oxide; hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 24h;

2,3-dihydro-2H-furan (1191-99-7) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With titanium(III)-tris-(tetrahydridoborate) In dichloromethane at -20℃; for 6h;	89%
With chloro-trimethyl-silane; Benzyltriethylammonium borohydride; oxygen In dichloromethane at 0℃; for 8h; other enol ethers;	73%
With chloro-trimethyl-silane; Benzyltriethylammonium borohydride; oxygen In dichloromethane at 0℃; for 8h;	73%
With hydrogen In 1,4-dioxane; water at 139.84℃; under 60006 Torr; for 4h;	24%
With water at 5℃;

4-(tetrahydropyran-2-yloxy)butan-1-ol (51326-51-3) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With ammonium nitrate; Montmorillonite-K10 for 0.0416667h; deprotection; microwave irradiation;	89%
With lithium bromide In methanol for 6h; Substitution; Heating;	80%

succinic acid (110-15-6) → tetrahydrofuran (109-99-9) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + butan-1-ol (71-36-3)

Conditions	Yield
With hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 96h; Catalytic behavior; Reagent/catalyst; Time; Temperature; Autoclave; Overall yield = 100 %;	A 0.2% B 3.1% C 89% D 7.6%
With hydrogen; 1.0percent Pd/ 3.0percent Re on Rutile TiO2 at 164 - 185℃; for 21 - 237h; Product distribution / selectivity;	A 2.95% B 0% C 81.5% D 3.35%
With hydrogen; 0percent Pd/5.0percent Re on Rutile TiO2 at 170 - 185℃; for 90 - 825h; Product distribution / selectivity;	A 3.38% B 0% C 64.14% D 2.86%

succinic acid (110-15-6) → tetrahydrofuran (109-99-9) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + butyric acid (107-92-6) + n-butane (106-97-8) + butan-1-ol (71-36-3)

Conditions	Yield
With hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Time; Autoclave; Overall yield = > 99 %;	A 0.2% B 3.1% C 89% D n/a E n/a F 7.6%

maleic acid (110-16-7) → tetrahydrofuran (109-99-9) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + malic acid (617-48-1) + succinic acid (110-15-6) + acetic acid (64-19-7) + butan-1-ol (71-36-3)

Conditions	Yield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; for 96 - 238h; Product distribution / selectivity;	A 0.6% B 0.04% C 0.62% D 0.19% E 88.49% F 0.12% G 0.11%

malonic acid dimethyl ester (108-59-8) → Butane-1,4-diol (110-63-4)

Conditions	Yield
With sodium tetrahydroborate; C36H30F6N10Ni4O10(2+)*2C2F3O2(1-); zinc(II) chloride In tetrahydrofuran at 45℃; for 12h;	87%

2-butenedioic acid (6915-18-0) → Butane-1,4-diol (110-63-4) + butan-1-ol (71-36-3)

Conditions	Yield
With hydrogen In water at 130℃; under 37503.8 Torr; for 18h; Pressure; Reagent/catalyst; Autoclave;	A 87% B 13%

Butane-1,4-diol (110-63-4) → cyclic sulfite of 1,4-butanediol (5732-45-6)

Conditions	Yield
With methanesulfonic acid; diisopropyl sulfite In toluene at 50℃; under 95 Torr;	100%
With pyridine; thionyl chloride In benzene for 4h; Ambient temperature;	70%
With thionyl chloride In dichloromethane Heating;	67%

Butane-1,4-diol (110-63-4) + chloroacetaldehyde dimethyl acetal (97-97-2) → 2-Chloromethyl-1,3-dioxepane (54237-96-6)

Conditions	Yield
With toluene-4-sulfonic acid Heating;	100%
With Dowex 50(H+) at 120℃; for 1h;	75%
Substitution;	38%
With toluene-4-sulfonic acid at 115℃; for 5h;

Butane-1,4-diol (110-63-4) + (E)-3-phenylacrylic acid (140-10-3) → Cinnamic acid 1,4-butane diol monoester

Conditions	Yield
With sulfuric acid In toluene Heating;	100%

Butane-1,4-diol (110-63-4) + 1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC8,9PC (75898-24-7) → DC8,9 phosphatidylhydroxybutanol (150891-85-3)

Conditions	Yield
With acetate buffer In isopropyl alcohol at 37℃; for 10h; phospholipase D;	100%

Butane-1,4-diol (110-63-4) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-(tert-butyldimethylsiloxy)-1-butanol (87184-99-4)

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃; for 1h;	100%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.666667h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 0℃; for 1.75h; Inert atmosphere;	100%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 0℃; for 1h;	100%

Butane-1,4-diol (110-63-4) + tert-butylchlorodiphenylsilane (58479-61-1) → 4-(tret-butyldiphenylsilyloxy)butan-1-ol (130372-07-5)

Conditions	Yield
With dmap; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 18℃; for 20h; Inert atmosphere;	100%

Butane-1,4-diol (110-63-4) + N,N-diisopropylcarbamoyl chloride (19009-39-3) → 5-hydroxybutyl N,N-diisopropylcarbamate

Conditions	Yield
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: N,N-diisopropylcarbamoyl chloride In tetrahydrofuran Heating; Further stages.;	100%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h; Stage #2: N,N-diisopropylcarbamoyl chloride In tetrahydrofuran Reflux;	91%

Butane-1,4-diol (110-63-4) + [(CH3COCHCOCH3)2Al(μ-OCH(CH3)2)2Al(OCH(CH3)2)2] → [Al2(OCH(CH3)2)2(CH3COCHCOCH3)2(O(CH2)4O)]2 (163462-32-6)

Conditions	Yield
In benzene byproducts: i-PrOH; moisture free; refluxing; solvent removal; elem. anal.;	100%

Butane-1,4-diol (110-63-4) + pivaloyl chloride (3282-30-2) → C4H10O2(C5H8O)2

Conditions	Yield
at 20℃; for 0.25h; Neat (no solvent);	100%

vinyl acetate (108-05-4) + Butane-1,4-diol (110-63-4) → butane-1,4-diol diacetate (628-67-1)

Conditions	Yield
With dilithium tetra(tert-butyl)zincate In toluene at 0℃; for 1h; Inert atmosphere;	100%
With steapsin lipase In hexane at 55℃; for 24h; Enzymatic reaction;	99 %Chromat.

Butane-1,4-diol (110-63-4) + 4-methoxy-benzoyl chloride (100-07-2) → 4-(p-methoxybenzyloxy)butan-1-ol (119649-45-5)

Conditions	Yield
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: 4-methoxy-benzoyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 0 - 20℃; for 17.5h;	100%

Butane-1,4-diol (110-63-4) + cyclohexanone (108-94-1) → 7,12-dioxaspiro<5.6>dodecane (181-28-2)

Conditions	Yield
With sulfonic group functionalized polyacrylonitrile preoxidated nanofiber mat In cyclohexane at 150℃; for 2h; Dean-Stark;	99.7%
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux;	98%
With cyclohexane for 2h; Dean-Stark;	92%

Butane-1,4-diol (110-63-4) → tetrahydrofuran (109-99-9)

Conditions	Yield
Trichlorbutylstannan at 80 - 84℃; for 9h;	99%
Trichlorbutylstannan at 80 - 84℃; for 19h; Mechanism; different molar ratios, different times;	99%
zirconium(IV) sulfate at 200℃; under 760.051 Torr; Product distribution / selectivity; Gas phase;	99.5%

2-chloroethanal (107-20-0) + Butane-1,4-diol (110-63-4) → 2-Chloromethyl-1,3-dioxepane (54237-96-6)

Conditions	Yield
With cyclohexane for 4h; Dean-Stark;	99%
With sulfonic group functionalized polyacrylonitrile preoxidated nanofiber mat In cyclohexane at 150℃; for 2h; Dean-Stark;	99.5%
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux;	98%
With [SOClMIm]Cl at 40℃; for 15h;
With melamine formaldehyde resin supported ionic liquid and cuprous catalyst In cyclohexane for 2h; Dean-Stark; Reflux;	80.24 %Chromat.

furfural (98-01-1) + Butane-1,4-diol (110-63-4) → 2-methylfuran (534-22-5) + 4-butanolide (96-48-0)

Conditions	Yield
With hydrogen; Cu-based catalyst at 210℃; Product distribution; Further Variations:; Temperatures; reaction in vapour phase, fixed bed reactor, coupled dehydrogenation reactions of title comp. and INO 160;	A 96.5% B 99.4%

Butane-1,4-diol (110-63-4) + titanium tetrachloride (7550-45-0) → C8H16O4Ti

Conditions	Yield
With calcium hydroxide for 2h; Autoclave; Cooling with ice; Inert atmosphere; Green chemistry;	99.3%

Butane-1,4-diol (110-63-4) + benzyl bromide (100-39-0) → 4-benzyloxy-butan-1-ol (4541-14-4)

Conditions	Yield
With potassium hydroxide for 3h; Ambient temperature;	99%
With potassium hydroxide at 20℃; Inert atmosphere;	99%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.833333h; Stage #2: benzyl bromide In tetrahydrofuran; mineral oil at 20℃; for 14h;	97%

Butane-1,4-diol (110-63-4) + benzoyl chloride (98-88-4) → 4-benzoyloxybutan-1-ol (32651-37-9)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine Inert atmosphere;	99%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃;	92%
With triethylamine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;	90%

Butane-1,4-diol (110-63-4) + triisopropylsilyl chloride (13154-24-0) → 4-((triisopropylsilyl)oxy)butan-1-ol (175849-51-1)

Conditions	Yield
With sodium hydride In tetrahydrofuran 1.) room temperature, 45 min, 2.) 0 deg C o room temperature, 30 min;	99%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.75h; Inert atmosphere; Stage #2: triisopropylsilyl chloride In tetrahydrofuran Inert atmosphere;	97%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Inert atmosphere; Cooling with ice; Stage #2: triisopropylsilyl chloride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	95.6%

Butane-1,4-diol (110-63-4) + (S)-2-methylbutyl tosylate (38261-81-3) → (S)-4-(2-methylbutoxy)butan-1-ol (104773-60-6)

Conditions	Yield
Stage #1: Butane-1,4-diol With sodium In tetrahydrofuran at 20℃; Stage #2: (S)-2-methylbutyl tosylate In tetrahydrofuran at 70 - 80℃;	99%
Stage #1: Butane-1,4-diol With sodium In tetrahydrofuran at 20℃; Stage #2: (S)-2-methylbutyl tosylate In tetrahydrofuran at 70 - 80℃;	78%

Butane-1,4-diol (110-63-4) + 2-methylbutanedioic acid (498-21-5, 636-60-2) → poly(butylene methylsuccinate), Mn 9.7E3 Da, Mw/Mn 1.5; monomer(s): 1,4-butanediol; methylsuccinic acid

Conditions	Yield
With scandium tris(trifluoromethanesulfonate) at 35℃; under 0.3 - 3 Torr; for 110h;	99%

Upstream product

• 50-00-0 Formaldehyde 
• 110-65-6 2-Butyne-1,4-diol 
• 431-03-8 2,3-Butanedione 
• 7440-02-0 Nickel 
• 1476-11-5 cis-1,4-Dichloro-2-butene 

Downstream Products

• 109-16-0 Triethylene glycol dimethacrylate 
• 110-52-1 1,4-Dibromobutane 
• 1191-99-7 2,3-Dihydrofuran 
• 55-98-1 Busulfan 
• 1070-70-8 1,4-BUTANEDIOL DIACRYLATE 
• 9003-39-8 Polyvinylpyrrolidone 
• 26062-94-2 POLY(1,4-BUTYLENE TEREPHTHALATE) 
• 109-99-9 Tetrahydrofuran 
• 2478-10-6 4-Hydroxybutyl acrylate 
• 9009-54-5 Polyurethane foams 
• 96-48-0 gamma-Butyrolactone 

Recommend Products

• 5835-79-0  4-(1-hydroxypropyl)morpholine 
• 53161-64-1  4,4'-butane-1,4-diyl-bis-morpholine 
• 110-91-8  morpholine 
• 1708-29-8  2,5-dihydrofuran 
• 109-99-9  tetrahydrofuran 
• 108-31-6  maleic anhydride 
• 110-52-1  1,4-dibromo-butane 
• 100-42-5  styrene 
• 110-65-6  1,4-dihydroxybut-2-yne 
• 7191-20-0  2-phenyl-1,3,2-dioxaphosphepin-2-oxide 
• 824-72-6  P,P-dichlorophenylphosphine oxide 
• 59413-41-1  2-phenoxy-1,3,2-dioxaphosphepin 
• 101-02-0  triphenyl phosphite 
• 101952-76-5  O,O'-bisnicotinoyl-1,4-butylenediol 

Related news

Rational engineering of diol dehydratase enables 1,4-Butanediol (cas 110-63-4) biosynthesis from xylose08/25/2019

Establishing novel synthetic routes for microbial production of chemicals often requires overcoming pathway bottlenecks by tailoring enzymes to enhance bio-catalysis or even achieve non-native catalysis. Diol dehydratases have been extensively studied for their interactions with C2 and C3 diols....detailed

Iridium-catalyzed dehydrogenative lactonization of 1,4-Butanediol (cas 110-63-4) and reversal hydrogenation: New hydrogen storage system using cheap organic resources08/21/2019

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Case ReportQuantification of GHB and GHB-GLUC in an 1,4-Butanediol (cas 110-63-4) intoxication: A case report08/20/2019

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