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1,4-Butanediol
Cas No: 110-63-4
No Data 1 Gram 1-1000 Metric Ton/Day Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
1,4-Butanediol CAS 110-63-4 1,4 BDO factory
Cas No: 110-63-4
USD $ 10.0-1000.0 / Gram 10 Gram 8000 Kilogram/Month HUBEI AOKS BIO-TECH CO.,LTD Contact Supplier
Bdo 99% Purity Bdo / 1, 4-Butanediol CAS: 110-63-4 with Safe Delivery
Cas No: 110-63-4
USD $ 50.0-50.0 / Metric Ton 1 Metric Ton 10000 Metric Ton/Month Xi'an SENYI New Material Technology Co., Ltd Contact Supplier
Factory supply 99.9% 1,4-Butanediol BDO in stock
Cas No: 110-63-4
No Data 1 Liter 10000 Liter/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
Wholesale Price Safe Delivery Bdo 1, 4-Butanediol CAS 110-63-4
Cas No: 110-63-4
USD $ 10.0-10.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Hebei Niuzhuo Technology Co. Ltd. Contact Supplier
99%1,4-Butanediol BDO factory in China
Cas No: 110-63-4
No Data 1 Kilogram 3 Metric Ton/Week Qingdao Beluga Import and Export Co., LTD Contact Supplier
1,4-Butanediol
Cas No: 110-63-4
No Data No Data No Data shanghai Longyu biotechnology Co.,Ltd Contact Supplier
Colourless Liquid Butyrolactone 99.9% Bdo 1, 4 Butanediol BDO CAS 110-63-4
Cas No: 110-63-4
USD $ 0.0-20.0 / Kilogram 1 Kilogram 90000 Metric Ton/Day Wuhan Lwax Pharma Tech Co.,LTD Contact Supplier
Good quality 1,4-Butanediol//cas.110-63-4
Cas No: 110-63-4
No Data 1 Metric Ton 2000 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
1,4-Butanediol
Cas No: 110-63-4
No Data 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

110-63-4 Usage

General Description

Odorless colorless liquid or solid (depending upon temperature).

Chemical Properties

1,4-butanediol (1,4-BD) is a colorless, viscous liquid derived from butane by placement of alcohol groups at each end of its molecular chain and is one of four stable isomers of butanediol.the hydroxyl function of each end group of the Butanediol reacts with different mono- and bifunctional reagents: for example with dicarboxylic acids to polyesters, with diisocyanates to polyurethanes, or with phosgene to polycarbonates. 1.4-Butanediol (BDO) is a high-quality intermediate. BDO and its derivatives are widely used for producing plastics, solvents, electronic chemicals and elastic fibers. Additionally BDO is also a building block for the synthesis of polyesterpolyols and polyetherpolyols. BASF is the most significant producer of 1,4-Butanediol and its derivatives worldwide.

Health Hazard

Ingestion of large amounts needed to produce any symptoms.

Air & Water Reactions

Highly flammable. 1,4-Butanediol is hygroscopic. Water soluble.

Purification Methods

Distil the glycol and store it over Linde type 4A molecular sieves, or crystallise it twice from anhydrous diethyl ether/acetone, and redistil it. It has been recrystallised from the melt and doubly distilled in vacuo in the presence of Na2SO4. [Beilstein 1 IV 2515.]

Reactivity Profile

1,4-Butanediol is heat and light sensitive. 1,4-Butanediol reacts with acid chlorides, acid anhydrides and chloroformates; reacts with oxidizing agents and reducing agents. 1,4-Butanediol is incompatible with isocyanates and acids; also incompatible with peroxides, perchloric acid, sulfuric acid, hypochlorous acid, nitric acid, caustics, acetaldehyde, nitrogen peroxide and chlorine.

Uses

  1. Butanediol and its derivatives is used in a broad spectrum of applications in the chemical industry; amongst others in the manufacturing of technical plastics, polyurethanes, solvents, electronic chemicals and elastic fibres.
  2. 1,4-Butanediol is used in the synthesis of epothilones, a new class of cancer drugs. Also used in the stereoselective synthesis of (-)-Brevisamide.
  3. 1,4-Butanediol's largest use is within tetrahydrofuran (THF) production, used to make polytetramethylene ether glycol, which goes mainly into spandex fibers, urethane elastomers, and copolyester ethers.
  4. It is commonly used as a solvent in the chemical industry to manufacture gamma-butyrolactone and elastic fibers like spandex.
  5. It is used as a cross-linking agent for thermoplastic urethanes, polyester plasticizers, paints and coatings.
  6. It undergoes dehydration in the presence of phosphoric acid yielded teterahydrofuran, which is an important solvent used for various applications.
  7. It acts an intermediate and is used to manufacture polytetramethylene ether glycol (PTMEG), polybutylene terephthalate (PBT) and polyurethane (PU).
  8. It finds application as an industrial cleaner and a glue remover.
  9. 1,4-butanediol is also used as a plasticiser (e.g. in polyesters and cellulosics), as a carrier solvent in printing ink, a cleaning agent, an adhesive (in leather, plastics, polyester laminates and polyurethane footwear), in agricultural and veterinary chemicals and in coatings (in paints, varnishes and films).

Production Methods

Methods of manufacturing:
The most prevalent 1,4-BD production route worldwide is BASF's Reppe process, which reacts acetylene and formaldehyde. Acetylene reacts with two equivalents of formaldehyde to form 1,4-butynediol, also known as but-2-yne- 1,4-diol. Hydrogenation of 1,4-butynediol gives 1,4-butanediol. 1,4-BD is also made on a large industrial scale by continuous hydrogenation of the 2-butyne- 1,4-diol over modified nickel catalysts. The one-stage flow process is carried out at 80 - 160 deg C and 300 bar.
Mitsubishi uses a three-step process:
(1) the catalytic reaction of butadiene and acetic acid yields 1,4-diacetoxy-2-butene;
(2) subsequent hydrogenation gives 1,4-diacetoxybutane; and
(3) hydrolysis leads to 1,4-butanediol.
InChI:InChI=1/C4H10O2/c5-3-1-2-4-6/h5-6H,1-4H2

110-63-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (L03491)  1,4-Butanediol, 99%    110-63-4 2500g 580.0CNY Detail
Alfa Aesar (L03491)  1,4-Butanediol, 99%    110-63-4 1000g 339.0CNY Detail
Alfa Aesar (L03491)  1,4-Butanediol, 99%    110-63-4 250g 211.0CNY Detail

110-63-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name butane-1,4-diol

1.2 Other means of identification

Product number -
Other names 1,4-Butanediol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adhesives and sealant chemicals,CBI,Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:110-63-4 SDS

110-63-4Synthetic route

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With C56H70Cl3N10Ru2(1+)*F6P(1-); potassium tert-butylate; hydrogen In tetrahydrofuran; dodecane at 70℃; under 37503.8 Torr; for 16h; Inert atmosphere; Glovebox; Autoclave;100%
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 15h; Glovebox; Autoclave;91%
With ethanol; sodium
4-butanolide
96-48-0

4-butanolide

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With sodium aluminum tetrahydride In tetrahydrofuran at 0℃; for 0.0833333h;100%
With C31H33ClN2O3RuS; potassium tert-butylate; hydrogen In isopropyl alcohol at 60℃; under 37503.8 Torr; for 48h; Inert atmosphere;100%
With C39H39N6ORu(1+)*Br(1-); potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 37503.8 Torr; for 16h; Reagent/catalyst;100%
succinic acid anhydride
108-30-5

succinic acid anhydride

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With sodium aluminum tetrahydride In tetrahydrofuran for 24h; Ambient temperature;100%
With hydrogen In water at 155℃; under 165017 Torr; Reagent/catalyst;95%
With sodium tetrahydroborate; C36H30F6N10Ni4O10(2+)*2C2F3O2(1-); zinc(II) chloride In tetrahydrofuran at 45℃; for 12h;78%
With [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)]; hydrogen In 1,4-dioxane at 195℃; under 37503.8 Torr; for 24h; Autoclave; Inert atmosphere;
With C38H54Cl2N2P2Ru; hydrogen; sodium hydride In toluene at 160 - 190℃; under 60006 Torr; for 23h; Autoclave; Sealed tube;98 %Spectr.
maleic acid
110-16-7

maleic acid

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With hydrogen In water100%
With hydrogen In water100%
With hydrogen In water100%
oxirane
75-21-8

oxirane

(naphthalene)Yb(THF)3

(naphthalene)Yb(THF)3

A

naphthalene
91-20-3

naphthalene

B

Butane-1,4-diol
110-63-4

Butane-1,4-diol

C

ytterbium hydroxide

ytterbium hydroxide

Conditions
ConditionsYield
With hydrogen cation In tetrahydrofuran shaken for 10 min at room temp.; centrifuged, decanted, soln. contains naphthalene, pptn. hydrolysed in THF: butanediol detd. by GLC in the organic layer and a pptn. (Yb(OH)3);A 83%
B 100%
C 75%
1,4-dihydroxybut-2-yne
110-65-6

1,4-dihydroxybut-2-yne

A

Butane-1,4-diol
110-63-4

Butane-1,4-diol

B

1,4-butenediol
6117-80-2

1,4-butenediol

Conditions
ConditionsYield
With hydrogen; copper-palladium; silica gel In ethanol at 25℃; under 760 Torr; Kinetics;A n/a
B 99%
With LaNi5 hydride In tetrahydrofuran; methanol at 0℃; for 6h;A 10%
B 67%
4-hydroxybutyl (4-oxo-3-phenyl-4H-thiochromen-2-yl)methylcarbonate
1033736-93-4

4-hydroxybutyl (4-oxo-3-phenyl-4H-thiochromen-2-yl)methylcarbonate

A

Butane-1,4-diol
110-63-4

Butane-1,4-diol

B

carbon dioxide
124-38-9

carbon dioxide

C

C16H10O3S
1033736-87-6

C16H10O3S

Conditions
ConditionsYield
In d(4)-methanol at 20℃; for 1h; Conversion of starting material; light irradiation;A 99%
B n/a
C 85%
maleic acid
110-16-7

maleic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

succinic acid
110-15-6

succinic acid

E

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With hydrogen; 0.5 percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity;A 0.37%
B 0.28%
C 0.37%
D 98.89%
E 0.08%
maleic acid
110-16-7

maleic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

methanol
67-56-1

methanol

D

Butane-1,4-diol
110-63-4

Butane-1,4-diol

E

malic acid
617-48-1

malic acid

F

succinic acid
110-15-6

succinic acid

G

acetic acid
64-19-7

acetic acid

H

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity;A 0.45%
B 0.06%
C 0%
D 0.21%
E 0.36%
F 98.73%
G 0.04%
H 0.08%
1,4-dihydroxybut-2-yne
110-65-6

1,4-dihydroxybut-2-yne

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With hydrogen; Ni catalyst as described in example 1 of U.S. Pat. No. 5,068,468 at 140℃; under 150015 Torr; for 336h; Conversion of starting material;98.3%
With hydrogen; Ni catalyst as described in example 1 of U.S. Pat. No. 5,068,468 In water at 140℃; under 150015 Torr; for 24 - 336h; Product distribution / selectivity;98.3%
With hydrogen In water at 100 - 135℃; under 60006 Torr; for 6h; Reagent/catalyst; Temperature; Pressure;90%
maleic acid
110-16-7

maleic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

4-hydroxybutanoic acid
591-81-1

4-hydroxybutanoic acid

E

succinic acid
110-15-6

succinic acid

F

acetic acid
64-19-7

acetic acid

G

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity;A 0.77%
B 0.38%
C 0.24%
D 0.05%
E 98.28%
F 0.02%
G 0.26%
1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-butane
122795-01-1

1,4-Bis-(tert-butyl-dimethyl-silanyloxy)-butane

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
sulfated SnO2 In methanol at 20℃; for 0.166667h;98%
With sodium hydride In N,N,N,N,N,N-hexamethylphosphoric triamide at 25℃; for 12h;70%
dimethyl cis-but-2-ene-1,4-dioate
624-48-6

dimethyl cis-but-2-ene-1,4-dioate

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

2-methoxytetrahydrofuran
13436-45-8

2-methoxytetrahydrofuran

C

4-butanolide
96-48-0

4-butanolide

D

propan-1-ol
71-23-8

propan-1-ol

E

2-(4'-hydroxybutoxy)-tetrahydrofuran
64001-06-5

2-(4'-hydroxybutoxy)-tetrahydrofuran

F

Butane-1,4-diol
110-63-4

Butane-1,4-diol

G

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With hydrogen; copper catalyst, T 4489, Sud-Chemie AG, Munich at 150 - 280℃; under 187519 Torr; Neat liquid(s) and gas(es)/vapour(s);A 1%
B n/a
C 0.4%
D n/a
E n/a
F 98%
G 0.5%
Dimethyl succinate
106-65-0

Dimethyl succinate

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 38002.6 Torr; for 6h; Autoclave;97%
With C13H34BFeNOP2; hydrogen In tetrahydrofuran at 100℃; under 22502.3 Torr; for 18h; Autoclave; Inert atmosphere;97%
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 37503.8 Torr; for 6h;97%
succinic acid
110-15-6

succinic acid

A

4-butanolide
96-48-0

4-butanolide

B

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With C36H54IrN2P2(1+)*C24H20B(1-); hydrogen; sodium hydride In toluene at 180℃; under 7500.75 - 45004.5 Torr; for 18h; Reagent/catalyst; Temperature; Pressure; Autoclave; Sealed tube;A 5%
B 95%
Stage #1: succinic acid In 1,4-dioxane at 500℃; for 4h;
Stage #2: With hydrogen In 1,4-dioxane at 200℃; under 60006 Torr; for 5h; Catalytic behavior; Reagent/catalyst;
A n/a
B 64.7%
With hydrogen In water at 130℃; under 37503.8 Torr; for 12h; Pressure; Reagent/catalyst; Temperature; Autoclave;A 34%
B 23%
succinic acid
110-15-6

succinic acid

A

Butane-1,4-diol
110-63-4

Butane-1,4-diol

B

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With perrhenic acid anhydride; hydrogen In 1,4-dioxane at 209.84℃; under 187519 Torr; for 4h; Catalytic behavior; Autoclave; Overall yield = 100 %;A 94%
B 6%
With hydrogen In water at 130℃; under 37503.8 Torr; for 12h; Pressure; Reagent/catalyst; Temperature; Autoclave;A 92%
B 5%
With hydrogen In water at 99.84℃; under 45004.5 Torr;
1-(phenylmethyl)-2,5-pyrrolidinedione
2142-06-5

1-(phenylmethyl)-2,5-pyrrolidinedione

A

Butane-1,4-diol
110-63-4

Butane-1,4-diol

B

benzylamine
100-46-9

benzylamine

Conditions
ConditionsYield
With C25H19BrMnN2O2P; potassium tert-butylate; hydrogen In tetrahydrofuran at 130℃; under 22502.3 Torr; for 48h; Inert atmosphere; Glovebox; Autoclave; Green chemistry;A 85%
B 93%
With [Ru(PtBuNNHtBu)H(CO)Cl]; potassium tert-butylate; hydrogen In 1,4-dioxane at 135℃; under 30003 Torr; for 40h; Autoclave;
1-tert-butyldimethylsilyloxy-4-triethylsilyloxybutane
117785-64-5

1-tert-butyldimethylsilyloxy-4-triethylsilyloxybutane

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With H-Y zeolite In methanol for 4h; Ambient temperature;92%
2-phenyl-1,3,2-benzodioxaborole
5747-23-9

2-phenyl-1,3,2-benzodioxaborole

A

Butane-1,4-diol
110-63-4

Butane-1,4-diol

B

phenol
108-95-2

phenol

Conditions
ConditionsYield
With oxygen; hydrazine hydrate In acetonitrile at 32℃; under 760.051 Torr; for 4h; Schlenk technique;A 92%
B 90%
maleic acid
110-16-7

maleic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

4-hydroxybutanoic acid
591-81-1

4-hydroxybutanoic acid

E

malic acid
617-48-1

malic acid

F

succinic acid
110-15-6

succinic acid

G

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With hydrogen; 0.5percent Pd/2.0percent Re on Rutile TiO2 at 110℃; Product distribution / selectivity;A 1.27%
B 4.78%
C 1.55%
D 1.24%
E 0.48%
F 90.6%
G 0.08%
1-(tert-Butyl-dimethyl-silanyloxy)-4-triisopropylsilanyloxy-butane

1-(tert-Butyl-dimethyl-silanyloxy)-4-triisopropylsilanyloxy-butane

A

Butane-1,4-diol
110-63-4

Butane-1,4-diol

B

4-((triisopropylsilyl)oxy)butan-1-ol
175849-51-1

4-((triisopropylsilyl)oxy)butan-1-ol

Conditions
ConditionsYield
With iron(III) chloride In methanol at 23℃; for 4h;A 4%
B 90%
cis-1,4-anhydroerythritol
4358-64-9

cis-1,4-anhydroerythritol

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With water; hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 4h; Reagent/catalyst; Solvent;90%
With cerium(IV) oxide; hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 24h;
2,3-dihydro-2H-furan
1191-99-7

2,3-dihydro-2H-furan

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With titanium(III)-tris-(tetrahydridoborate) In dichloromethane at -20℃; for 6h;89%
With chloro-trimethyl-silane; Benzyltriethylammonium borohydride; oxygen In dichloromethane at 0℃; for 8h; other enol ethers;73%
With chloro-trimethyl-silane; Benzyltriethylammonium borohydride; oxygen In dichloromethane at 0℃; for 8h;73%
With hydrogen In 1,4-dioxane; water at 139.84℃; under 60006 Torr; for 4h;24%
With water at 5℃;
4-(tetrahydropyran-2-yloxy)butan-1-ol
51326-51-3

4-(tetrahydropyran-2-yloxy)butan-1-ol

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With ammonium nitrate; Montmorillonite-K10 for 0.0416667h; deprotection; microwave irradiation;89%
With lithium bromide In methanol for 6h; Substitution; Heating;80%
succinic acid
110-15-6

succinic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 96h; Catalytic behavior; Reagent/catalyst; Time; Temperature; Autoclave; Overall yield = 100 %;A 0.2%
B 3.1%
C 89%
D 7.6%
With hydrogen; 1.0percent Pd/ 3.0percent Re on Rutile TiO2 at 164 - 185℃; for 21 - 237h; Product distribution / selectivity;A 2.95%
B 0%
C 81.5%
D 3.35%
With hydrogen; 0percent Pd/5.0percent Re on Rutile TiO2 at 170 - 185℃; for 90 - 825h; Product distribution / selectivity;A 3.38%
B 0%
C 64.14%
D 2.86%
succinic acid
110-15-6

succinic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

butyric acid
107-92-6

butyric acid

E

n-butane
106-97-8

n-butane

F

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Time; Autoclave; Overall yield = > 99 %;A 0.2%
B 3.1%
C 89%
D n/a
E n/a
F 7.6%
maleic acid
110-16-7

maleic acid

A

tetrahydrofuran
109-99-9

tetrahydrofuran

B

4-butanolide
96-48-0

4-butanolide

C

Butane-1,4-diol
110-63-4

Butane-1,4-diol

D

malic acid
617-48-1

malic acid

E

succinic acid
110-15-6

succinic acid

F

acetic acid
64-19-7

acetic acid

G

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; for 96 - 238h; Product distribution / selectivity;A 0.6%
B 0.04%
C 0.62%
D 0.19%
E 88.49%
F 0.12%
G 0.11%
malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With sodium tetrahydroborate; C36H30F6N10Ni4O10(2+)*2C2F3O2(1-); zinc(II) chloride In tetrahydrofuran at 45℃; for 12h;87%
2-butenedioic acid
6915-18-0

2-butenedioic acid

A

Butane-1,4-diol
110-63-4

Butane-1,4-diol

B

butan-1-ol
71-36-3

butan-1-ol

Conditions
ConditionsYield
With hydrogen In water at 130℃; under 37503.8 Torr; for 18h; Pressure; Reagent/catalyst; Autoclave;A 87%
B 13%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

cyclic sulfite of 1,4-butanediol
5732-45-6

cyclic sulfite of 1,4-butanediol

Conditions
ConditionsYield
With methanesulfonic acid; diisopropyl sulfite In toluene at 50℃; under 95 Torr;100%
With pyridine; thionyl chloride In benzene for 4h; Ambient temperature;70%
With thionyl chloride In dichloromethane Heating;67%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

chloroacetaldehyde dimethyl acetal
97-97-2

chloroacetaldehyde dimethyl acetal

2-Chloromethyl-1,3-dioxepane
54237-96-6

2-Chloromethyl-1,3-dioxepane

Conditions
ConditionsYield
With toluene-4-sulfonic acid Heating;100%
With Dowex 50(H+) at 120℃; for 1h;75%
Substitution;38%
With toluene-4-sulfonic acid at 115℃; for 5h;
Butane-1,4-diol
110-63-4

Butane-1,4-diol

(E)-3-phenylacrylic acid
140-10-3

(E)-3-phenylacrylic acid

Cinnamic acid 1,4-butane diol monoester

Cinnamic acid 1,4-butane diol monoester

Conditions
ConditionsYield
With sulfuric acid In toluene Heating;100%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC8,9PC
75898-24-7

1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC8,9PC

DC8,9 phosphatidylhydroxybutanol
150891-85-3

DC8,9 phosphatidylhydroxybutanol

Conditions
ConditionsYield
With acetate buffer In isopropyl alcohol at 37℃; for 10h; phospholipase D;100%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

4-(tert-butyldimethylsiloxy)-1-butanol
87184-99-4

4-(tert-butyldimethylsiloxy)-1-butanol

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0℃; for 1h;100%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.666667h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 0℃; for 1.75h; Inert atmosphere;
100%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 0℃; for 1h;
100%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

4-(tret-butyldiphenylsilyloxy)butan-1-ol
130372-07-5

4-(tret-butyldiphenylsilyloxy)butan-1-ol

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 18℃; for 20h; Inert atmosphere;100%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

N,N-diisopropylcarbamoyl chloride
19009-39-3

N,N-diisopropylcarbamoyl chloride

5-hydroxybutyl N,N-diisopropylcarbamate

5-hydroxybutyl N,N-diisopropylcarbamate

Conditions
ConditionsYield
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran at 0℃; for 1h;
Stage #2: N,N-diisopropylcarbamoyl chloride In tetrahydrofuran Heating; Further stages.;
100%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h;
Stage #2: N,N-diisopropylcarbamoyl chloride In tetrahydrofuran Reflux;
91%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

[(CH3COCHCOCH3)2Al(μ-OCH(CH3)2)2Al(OCH(CH3)2)2]

[(CH3COCHCOCH3)2Al(μ-OCH(CH3)2)2Al(OCH(CH3)2)2]

[Al2(OCH(CH3)2)2(CH3COCHCOCH3)2(O(CH2)4O)]2
163462-32-6

[Al2(OCH(CH3)2)2(CH3COCHCOCH3)2(O(CH2)4O)]2

Conditions
ConditionsYield
In benzene byproducts: i-PrOH; moisture free; refluxing; solvent removal; elem. anal.;100%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

pivaloyl chloride
3282-30-2

pivaloyl chloride

C4H10O2(C5H8O)2

C4H10O2(C5H8O)2

Conditions
ConditionsYield
at 20℃; for 0.25h; Neat (no solvent);100%
vinyl acetate
108-05-4

vinyl acetate

Butane-1,4-diol
110-63-4

Butane-1,4-diol

butane-1,4-diol diacetate
628-67-1

butane-1,4-diol diacetate

Conditions
ConditionsYield
With dilithium tetra(tert-butyl)zincate In toluene at 0℃; for 1h; Inert atmosphere;100%
With steapsin lipase In hexane at 55℃; for 24h; Enzymatic reaction;99 %Chromat.
Butane-1,4-diol
110-63-4

Butane-1,4-diol

4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

4-(p-methoxybenzyloxy)butan-1-ol
119649-45-5

4-(p-methoxybenzyloxy)butan-1-ol

Conditions
ConditionsYield
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran at 0℃; for 0.166667h;
Stage #2: 4-methoxy-benzoyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 0 - 20℃; for 17.5h;
100%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

cyclohexanone
108-94-1

cyclohexanone

7,12-dioxaspiro<5.6>dodecane
181-28-2

7,12-dioxaspiro<5.6>dodecane

Conditions
ConditionsYield
With sulfonic group functionalized polyacrylonitrile preoxidated nanofiber mat In cyclohexane at 150℃; for 2h; Dean-Stark;99.7%
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux;98%
With cyclohexane for 2h; Dean-Stark;92%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

tetrahydrofuran
109-99-9

tetrahydrofuran

Conditions
ConditionsYield
Trichlorbutylstannan at 80 - 84℃; for 9h;99%
Trichlorbutylstannan at 80 - 84℃; for 19h; Mechanism; different molar ratios, different times;99%
zirconium(IV) sulfate at 200℃; under 760.051 Torr; Product distribution / selectivity; Gas phase;99.5%
2-chloroethanal
107-20-0

2-chloroethanal

Butane-1,4-diol
110-63-4

Butane-1,4-diol

2-Chloromethyl-1,3-dioxepane
54237-96-6

2-Chloromethyl-1,3-dioxepane

Conditions
ConditionsYield
With cyclohexane for 4h; Dean-Stark;99%
With sulfonic group functionalized polyacrylonitrile preoxidated nanofiber mat In cyclohexane at 150℃; for 2h; Dean-Stark;99.5%
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux;98%
With [SOClMIm]Cl at 40℃; for 15h;
With melamine formaldehyde resin supported ionic liquid and cuprous catalyst In cyclohexane for 2h; Dean-Stark; Reflux;80.24 %Chromat.
furfural
98-01-1

furfural

Butane-1,4-diol
110-63-4

Butane-1,4-diol

A

2-methylfuran
534-22-5

2-methylfuran

B

4-butanolide
96-48-0

4-butanolide

Conditions
ConditionsYield
With hydrogen; Cu-based catalyst at 210℃; Product distribution; Further Variations:; Temperatures; reaction in vapour phase, fixed bed reactor, coupled dehydrogenation reactions of title comp. and INO 160;A 96.5%
B 99.4%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

titanium tetrachloride
7550-45-0

titanium tetrachloride

C8H16O4Ti

C8H16O4Ti

Conditions
ConditionsYield
With calcium hydroxide for 2h; Autoclave; Cooling with ice; Inert atmosphere; Green chemistry;99.3%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

benzyl bromide
100-39-0

benzyl bromide

4-benzyloxy-butan-1-ol
4541-14-4

4-benzyloxy-butan-1-ol

Conditions
ConditionsYield
With potassium hydroxide for 3h; Ambient temperature;99%
With potassium hydroxide at 20℃; Inert atmosphere;99%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.833333h;
Stage #2: benzyl bromide In tetrahydrofuran; mineral oil at 20℃; for 14h;
97%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

benzoyl chloride
98-88-4

benzoyl chloride

4-benzoyloxybutan-1-ol
32651-37-9

4-benzoyloxybutan-1-ol

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine Inert atmosphere;99%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃;92%
With triethylamine In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;90%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

triisopropylsilyl chloride
13154-24-0

triisopropylsilyl chloride

4-((triisopropylsilyl)oxy)butan-1-ol
175849-51-1

4-((triisopropylsilyl)oxy)butan-1-ol

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran 1.) room temperature, 45 min, 2.) 0 deg C o room temperature, 30 min;99%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.75h; Inert atmosphere;
Stage #2: triisopropylsilyl chloride In tetrahydrofuran Inert atmosphere;
97%
Stage #1: Butane-1,4-diol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: triisopropylsilyl chloride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
95.6%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

(S)-2-methylbutyl tosylate
38261-81-3

(S)-2-methylbutyl tosylate

(S)-4-(2-methylbutoxy)butan-1-ol
104773-60-6

(S)-4-(2-methylbutoxy)butan-1-ol

Conditions
ConditionsYield
Stage #1: Butane-1,4-diol With sodium In tetrahydrofuran at 20℃;
Stage #2: (S)-2-methylbutyl tosylate In tetrahydrofuran at 70 - 80℃;
99%
Stage #1: Butane-1,4-diol With sodium In tetrahydrofuran at 20℃;
Stage #2: (S)-2-methylbutyl tosylate In tetrahydrofuran at 70 - 80℃;
78%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

2-methylbutanedioic acid
498-21-5, 636-60-2

2-methylbutanedioic acid

poly(butylene methylsuccinate), Mn 9.7E3 Da, Mw/Mn 1.5; monomer(s): 1,4-butanediol; methylsuccinic acid

poly(butylene methylsuccinate), Mn 9.7E3 Da, Mw/Mn 1.5; monomer(s): 1,4-butanediol; methylsuccinic acid

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) at 35℃; under 0.3 - 3 Torr; for 110h;99%

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