1-cyclopropyl-6-fluoro-8-Methoxy-7-(2-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:1-cyclopropyl-6-fluoro-8-Methoxy-7-(2-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1029364-65-5
Molecular Formula:C₁₉H₂₂FN₃O₄
Molecular Weight:375.4
Hs Code.:
Mol file:1029364-65-5.mol

Synonyms:1-cyclopropyl-6-fluoro-8-Methoxy-7-(2-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(2-Methyl-1-piperazinyl)-4-oxo-;4-forMyl-1-(Methoxycarbonyl)-1H-indol-2-ylboronic acid;1-Cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(2-Methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid;Iso Gatifloxacin;Gatifloxacin USP IMpurity E;Iso Gatifloxacin DISCONTINUED

Suppliers and Price of 1-cyclopropyl-6-fluoro-8-Methoxy-7-(2-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 1-cyclopropyl-6-fluoro-8-Methoxy-7-(2-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

Boiling Point:607.8±55.0 °C(Predicted)
PKA:6.43±0.50(Predicted)
PSA：83.80000
Density:1.386±0.06 g/cm3(Predicted)
LogP:2.37420

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Iso Gatifloxacin is an impurity of Gatifloxacin (G250000).

Technology Process of 1-cyclopropyl-6-fluoro-8-Methoxy-7-(2-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 5 articles about 1-cyclopropyl-6-fluoro-8-Methoxy-7-(2-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219097-38-7
C₂₄H₃₀FN₃O₆

: 1029364-65-5
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: With hydrogenchloride; at 0 - 20 ℃; for 1h;
DOI:10.14233/ajchem.2014.15572

Reference yield:

: 109-07-9
(RS)-2-methylpiperazine

: 1029364-65-5
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 1 h / 0 °C / Inert atmosphere

2: dimethyl sulfoxide / 72 h / 0 - 40 °C / Inert atmosphere

3: methanol / 12 h / 60 - 65 °C / Inert atmosphere

4: hydrogenchloride / 1 h / 0 - 20 °C

With hydrogenchloride; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.14233/ajchem.2014.15572

Reference yield:

: 120737-59-9
3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1029364-65-5
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(2-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 72 h / 0 - 40 °C / Inert atmosphere

2: methanol / 12 h / 60 - 65 °C / Inert atmosphere

3: hydrogenchloride / 1 h / 0 - 20 °C

With hydrogenchloride; In methanol; dimethyl sulfoxide;
DOI:10.14233/ajchem.2014.15572