CILOMILAST

Base Information

• Chemical Name: CILOMILAST
• CAS No.: 164414-71-5
• Molecular Weight: 343.42
• Mol file: 164414-71-5.mol

Synonyms:CFBUZOUXXHZCFB-UHFFFAOYSA-N;Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

Chemical Property of CILOMILAST

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of CILOMILAST

There total 42 articles about CILOMILAST which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

lithium cis-4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)-r-1-cyclohexanecarboxylate → cilomilast (153259-65-5,164414-71-5)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; for 0.166667h;

DOI:10.1021/op025584z

Reference yield: 69.0%

cis-(+/-)-6-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-oxospiro[2,5]octane-2,6-dicarbonitrile → cilomilast (153259-65-5,164414-71-5)

Guidance literature:

With water; lithium bromide; In N,N-dimethyl-formamide; acetonitrile; at 90 - 95 ℃; for 8h;

Reference yield: 69.0%

cis-(+/-)-6-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-oxospiro[2,5]octane-2,6-dicarbonitrile → cilomilast (153259-65-5,164414-71-5) + cilomilast (153259-69-9,164414-71-5)

Guidance literature:

With water; lithium bromide; In N,N-dimethyl-formamide; acetonitrile; at 90 - 95 ℃; for 16h;

DOI:10.1021/jo025737g

upstream raw materials:

methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexan-1-one

2-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexylidene]-1,3-dithiane

methyl 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohex-1-ene-1-carboxylate

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