3-Pyridazinecarboxylic acid, 1,6-dihydro-1-Methyl-6-oxo-, Methyl ester

Base Information

• Chemical Name: 3-Pyridazinecarboxylic acid, 1,6-dihydro-1-Methyl-6-oxo-, Methyl ester
• CAS No.: 74173-58-3
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.152
• Mol file: 74173-58-3.mol

Synonyms:3-Pyridazinecarboxylic acid, 1,6-dihydro-1-Methyl-6-oxo-, Methyl ester;Methyl 1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

Chemical Property of 3-Pyridazinecarboxylic acid, 1,6-dihydro-1-Methyl-6-oxo-, Methyl ester

Chemical Property:

• PSA: 61.19000
• LogP: -0.43310

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridazinecarboxylic acid, 1,6-dihydro-1-Methyl-6-oxo-, Methyl ester

There total 1 articles about 3-Pyridazinecarboxylic acid, 1,6-dihydro-1-Methyl-6-oxo-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

6-oxo-1,6-dihydropyridazine-3-carboxylic acid (37972-69-3) + dimethyl sulfate (77-78-1) → methyl 6-methoxypyridazine-3-carboxylate (19194-96-8) + methyl 1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (74173-58-3)

Guidance literature:

With sodium carbonate; In water; at 20 ℃; for 2h;

DOI:10.1016/j.molstruc.2011.05.016

Reference yield: 53.0%

methyl 1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (74173-58-3) + 4-chloro-5-(3-fluorobenzyl)thiazol-2-amine → N-(4-chloro-5-(3-fluorobenzyl)thiazol-2-yl)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide

Guidance literature:

4-chloro-5-(3-fluorobenzyl)thiazol-2-amine; With trimethylaluminum; In toluene; at 20 ℃; Inert atmosphere;

methyl 1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate; In toluene; at 100 ℃;

Reference yield: 41.0%

methyl 1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (74173-58-3) + 5-(3-chloro-5-fluorobenzyl)pyridin-2-amine → N-(5-(3-chloro-5-fluorobenzyl)pyridin-2-yl)-1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide

Guidance literature:

5-(3-chloro-5-fluorobenzyl)pyridin-2-amine; With trimethylaluminum; In toluene; at 20 ℃; for 1h; Inert atmosphere;

methyl 1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate; In toluene; at 100 ℃; for 2h;

upstream raw materials:

6-oxo-1,6-dihydropyridazine-3-carboxylic acid

dimethyl sulfate

Downstream raw materials:

1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide

Refernces