methyl 6-methoxypyridazine-3-carboxylate

Base Information

• Chemical Name: methyl 6-methoxypyridazine-3-carboxylate
• CAS No.: 19194-96-8
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.15000
• Mol file: 19194-96-8.mol

Synonyms:6-methoxy-pyridazine-3-carboxylic acid methyl ester;6-Methoxy-pyridazin-3-carbonsaeure-methylester;6-methoxy-3-(methoxycarbonyl)pyridazine;

Chemical Property of methyl 6-methoxypyridazine-3-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 119-120 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 341.8±22.0 °C(Predicted)
• PKA: 1.16±0.10(Predicted)
• PSA: 61.31000
• Density: 1.220±0.06 g/cm3(Predicted)
• LogP: 0.27180

Purity/Quality:

99%, ^*data from raw suppliers

Methyl6-methoxypyridazine-3-carboxylate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 6-methoxypyridazine-3-carboxylate

There total 15 articles about methyl 6-methoxypyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 6-methoxypyridazine-3-carboxylic acid (56434-28-7) → methyl 6-methoxypyridazine-3-carboxylate (19194-96-8)

Guidance literature:

6-methoxypyridazine-3-carboxylic acid; With thionyl chloride; for 3h; Heating / reflux;

methanol; at 20 ℃;

Reference yield: 56.0%

trans-4-[tris(dimethylamino)phosphoranylidene]azinopent-2-endioic acid dimethyl ester (1154750-66-9) → methyl 6-methoxypyridazine-3-carboxylate (19194-96-8)

Guidance literature:

In tert-butyl methyl ether; at 50 - 55 ℃; for 16h; UV-irradiation;

DOI:10.1002/chem.201503448

Reference yield: 37.0%

6-oxo-1,6-dihydropyridazine-3-carboxylic acid (37972-69-3) + dimethyl sulfate (77-78-1) → methyl 6-methoxypyridazine-3-carboxylate (19194-96-8) + methyl 1-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (74173-58-3)

Guidance literature:

With sodium carbonate; In water; at 20 ℃; for 2h;

DOI:10.1016/j.molstruc.2011.05.016

upstream raw materials:

sodium methylate

methyl 6-chloro-3-pyridazinecarboxylate

methanol

6-methoxypyridazine-3-carboxylic acid

Downstream raw materials:

6-methoxypyridazine-3-carboxylic acid

methyl 6‐oxo‐1,6‐dihydropyridazine‐3‐carboxylate

3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

3-chloro-5-((6-oxo-1-((6-oxo-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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