ForMoterol FuMarate (Mixture of DiastereoMers)

Base Information

• Chemical Name: ForMoterol FuMarate (Mixture of DiastereoMers)
• CAS No.: 169375-55-7
• Molecular Formula: C23H28N2O8
• Molecular Weight: 460.484
• Mol file: 169375-55-7.mol

Synonyms:ForMoterol FuMarate (Mixture of DiastereoMers);N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-Methoxyphenyl)-1-Methylethyl]aMino]ethyl]phenyl]-forMaMide (2E)-2-Butenedioate Salt

Chemical Property of ForMoterol FuMarate (Mixture of DiastereoMers)

Chemical Property:

• PSA: 165.42000
• LogP: 3.03490
• Storage Temp.: -20°C, Hygroscopic
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

FormoterolFumarate(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Formoterol fumarate (mixture of diastereomers) is an impurity of Formoterol fumarate dihydrate (F693400).

Technology Process of ForMoterol FuMarate (Mixture of DiastereoMers)

There total 6 articles about ForMoterol FuMarate (Mixture of DiastereoMers) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.68%

formoterol (128954-45-0,67346-49-0) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → formoterol fumarate (169375-55-7,87833-61-2)

Guidance literature:

In methanol; dimethyl sulfoxide; at 20 - 30 ℃; for 0.166667h;

Reference yield:

C32H36N2O3*C4H4O4 → formoterol fumarate (169375-55-7,87833-61-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium carbonate / water; dichloromethane / 30 - 40 °C

2: HATU / chloroform / 0 - 10 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 30 - 35 °C / 3750.38 - 3900.39 Torr

4: methanol; dimethyl sulfoxide / 0.17 h / 20 - 30 °C

With palladium 10% on activated carbon; hydrogen; sodium carbonate; HATU; In methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

[2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amine (43229-65-8) → formoterol fumarate (169375-55-7,87833-61-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 - 130 °C

2: iron; ammonium chloride / ethanol; water / 75 - 85 °C

3: HATU / chloroform / 0 - 10 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 30 - 35 °C / 3750.38 - 3900.39 Torr

5: methanol; dimethyl sulfoxide / 0.17 h / 20 - 30 °C

With palladium 10% on activated carbon; hydrogen; iron; ammonium chloride; HATU; In methanol; ethanol; chloroform; water; dimethyl sulfoxide; ethyl acetate;

upstream raw materials:

formoterol

(2E)-but-2-enedioic acid

[2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amine

2-(3-benzyloxy-4-nitrophenyl)oxirane