2-Nitro-4-(trifluoromethylthio)aniline

Base Information

• Chemical Name: 2-Nitro-4-(trifluoromethylthio)aniline
• CAS No.: 404-74-0
• Molecular Formula: C7H5F3N2O2S
• Molecular Weight: 238.19
• Mol file: 404-74-0.mol

Synonyms:2-Nitro-4-(trifluoromethylthio)aniline

Chemical Property of 2-Nitro-4-(trifluoromethylthio)aniline

Chemical Property:

• PSA: 97.14000
• LogP: 3.89330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Nitro-4-((trifluoromethyl)thio)aniline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Nitro-4-(trifluoromethylthio)aniline

There total 2 articles about 2-Nitro-4-(trifluoromethylthio)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{2-nitro-4-[(trifluoromethyl)sulfanyl]phenyl}acetamide (448-41-9) → 2-nitro-4-trifluoromethylsulfanyl-aniline (404-74-0)

Guidance literature:

With potassium hydroxide;

DOI:10.1080/00304940309355835

Reference yield:

4-trifluoromethylthioacetanilide (351-81-5) → 2-nitro-4-trifluoromethylsulfanyl-aniline (404-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃

2: aq.-ethanolic KOH

With potassium hydroxide; nitric acid;

DOI:10.1080/00304940309355835

Reference yield:

2-nitro-4-trifluoromethylsulfanyl-aniline (404-74-0) → 3-(trifluoromethylthio)aniline (369-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; sulfuric acid; aqueous sodium nitrite solution / zuletzt unter Erwaermen

2: SnCl₂; aq.-ethanolic HCl

With hydrogenchloride; ethanol; sulfuric acid; tin(ll) chloride; sodium nitrite;

upstream raw materials:

N-{2-nitro-4-[(trifluoromethyl)sulfanyl]phenyl}acetamide

4-trifluoromethylthioacetanilide

Downstream raw materials:

(3-nitrophenyl)(trifluoromethyl)sulfane

4-trifluoromethylsulfanyl-o-phenylenediamine

2-Nitro-4-trifluormethylmercapto-diphenylamin

4-Dimethylamino-2'-nitro-4'-trifluormethylmercapto-azobenzol

Refernces