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Usage

Uses

Used in Organic Synthesis:
3-(TRIFLUOROMETHYLTHIO)ANILINE is used as an intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows it to participate in a range of reactions, making it a valuable building block for the creation of more complex molecules.
Used in Regioselective Friedel-Crafts Alkylation:
In the field of chemical research and pharmaceutical development, 3-(TRIFLUOROMETHYLTHIO)ANILINE is employed in the regioselective Friedel-Crafts alkylation in hexafluoroacetone sesquihydrate. This process involves the selective addition of an alkyl group to a specific position on a molecule, which is crucial for the synthesis of specific target compounds with desired properties and applications.
Used in Pharmaceutical Industry:
3-(TRIFLUOROMETHYLTHIO)ANILINE is also used in the pharmaceutical industry as a key component in the development of new drugs. Its unique chemical properties enable it to be incorporated into the molecular structure of potential therapeutic agents, contributing to their overall efficacy and selectivity.
Used in Chemical Research:
In the realm of chemical research, 3-(TRIFLUOROMETHYLTHIO)ANILINE serves as a valuable compound for studying various reaction mechanisms and exploring new synthetic pathways. Its reactivity and structural features make it an attractive candidate for investigating novel chemical transformations and understanding the underlying principles governing these processes.

InChI:InChI=1/C7H6F3NS/c8-7(9,10)12-6-3-1-2-5(11)4-6/h1-4H,11H2

Upstream product

• 370-47-8 (3-nitrophenyl)(trifluoromethyl)sulfane 
• 887144-97-0 Togni's reagent 
• 22948-02-3 3-aminothiophenol 
• 16671-77-5 3-nitrophenyl thiocyanate 
• 404-74-0 2-nitro-4-trifluoromethylsulfanyl-aniline 
• 3814-18-4 3-nitrothiophenol 
• 90109-81-2 (3-nitro-phenyl)-trichloromethyl sulfide 
• 2524-76-7 1-(methylsulfanyl)-3-nitrobenzene 
• 75-63-8 Bromotrifluoromethane 
• 79576-16-2 potassium 3-aminothiophenoxide 

Downstream Products

• 64627-93-6 1-(2-Chloro-benzoyl)-3-(3-trifluoromethylsulfanyl-phenyl)-urea 
• 64627-94-7 1-(2,6-Dichloro-benzoyl)-3-(3-trifluoromethylsulfanyl-phenyl)-urea 
• 64627-92-5 1-(2-Methyl-benzoyl)-3-(3-trifluoromethylsulfanyl-phenyl)-urea 
• 64627-90-3 1-(2,6-Difluoro-benzoyl)-3-(3-trifluoromethylsulfanyl-phenyl)-urea 
• 64627-91-4 1-(2-Fluoro-benzoyl)-3-(3-trifluoromethylsulfanyl-phenyl)-urea 
• 64627-95-8 1-(2-Bromo-benzoyl)-3-(3-trifluoromethylsulfanyl-phenyl)-urea 
• 55225-25-7 3-(trifluoromethyl)-4-ethoxy-3'-(trifluoromethylthio)carbanilide 
• 55225-82-6 4,4-sulfonylbis(3'-(trifluoromethylthio)carbanilide) 
• 58140-02-6 C₁₆H₉F₆N₅S₂ 
• 3823-40-3 3-(trifluoromethylthio) phenol 
• 2402-63-3 N,N-dimethyl-3-((trifluoromethyl)thio)aniline 
• 50786-80-6 N-(m-trifluoromethylthio-phenyl)-piperazine 
• 1256932-78-1 ethyl 2-ethoxycarbonyl-3-[3-(trifluoromethylthio)anilino]-2-propenoate 

Relevant academic research and scientific papers

BORON CONTAINING COMPOUNDS AND THEIR USES

The present disclosure relates to novel boron-containing compounds and their novel uses, e.g., as active ingredients that have pesticidal activity. The disclosure also relates to agrochemical compositions and their use in agriculture or horticulture for the control or prevention of infestation of plants, plant parts, plant propagation materials, harvested food crops, or seeds by pests, specifically fungi and nematodes. The disclosure further relates to methods for promoting plant performance and/or curatively or preventively controlling phytopathogens, (particularly fungi and nematodes) on or in a plant, plant parts, plant propagation materials, seeds, harvested fruits, or vegetables.

Recent advances in electrophilic CF3-transfer using hypervalent iodine(III) reagents

The development of new methodologies for an efficient introduction of CF3 groups into complex molecules constitutes one of the most challenging tasks of modern organic chemistry. Recently, we reported the access to a new class of electrophilic CF3-transfer reagents based on hypervalent iodine. The versatile application of these reagents to C-centred nucleophiles, such as β-keto esters, silyl enol ethers and α-nitro esters, as well as to thiols and primary and secondary phosphines is described. Experiments with phenols afforded corresponding trifluomethylethers in very low yields. Schweizerische Chemische Gesellschaft.

Mild electrophilic trifluoromethylation of carbon- and sulfur-centered nucleophiles by a hypervalent iodine(III)-CF3 reagent

Inexpensive, recyclable, and activable: these are the features of a new mild electrophilic trifluoromethylation reagent that can be used to transfer a CF3 group to C-centered nucleophiles, such as β-keto esters and α-nitro esters, and to S-centered nucleophiles (see scheme). (Chemical Equation Presented).

Chemistry of Halogenoperfluoroalkanes> Synthesis of Fluorinated Ethers and Thioethers via Radical or Anionic Intermediates

Condensation of bromotrifluoromethane with potassium thiophenoxides in DMF is performed under pressure (2-3 atm) in a glass apparatus.Inhibition by nitrobenzene shows that a SRN1 mechanism is involved in the formation of aryl trifluoromethyl sulfides.Dichlorodifluoromethane itself reacts through a similar process to give aryl chlorodifluoromethyl sulfides.Condensation of 1,1,2-trichlorotrifluoroethane with potassium thiophenoxide or phenoxide occurs even in the presence of nitrobenzene.The formation of aryl 2,2-dichloro-1,1,2-trifluoroethyl sulfides or ethers can be explained by a chain carbanionic mechanism.